1341607
Adjunct Professor
Adrian Herington
Faculty of Health,
School of Biomedical Sciences
Biography
Research theme: HealthResearch discipline: Cell and Molecular Biosciences
Research program: Hormone Dependent Cancer
Research areas
- The expression, regulation and function of the growth factor ghrelin, its receptor and a novel overexpressed ghrelin antisense gene, in hormone dependent cancer.
- Identification and functional studies of a novel ghrelin antisense gene overexpressed in breast and prostate cancer.
- The expression, regulation and function of the receptor tyrosine kinase EphB4 in hormone dependent cancers of the breast and prostate.
Areas of expertise
- Hormone–Dependent Cancer
- Growth Hormone Receptors / Action
- Ghrelin
- Insulin–Like Growth Factors
- 2004-2006: NHMRC: Regulation and functional roles of ADAM10 in prostate cancer
- 2005-2006: Queensland Cancer Fund: Heterodimerisation of the GHSR and cross–talk with the MAPK (mitogen–activated kinase) signalling pathway in prostate cancer
- 2006-2007: Queensland Cancer Fund: The ghrelin axis and an exon 3 deleted ghrelin variant in breast cancer.
- 2007-2008: Cancer Council Queensland: The opposing roles of a novel preproghrelin isoform and obestatin, a preproghrelin-derived hormone, in prostate cancer
- 2009-2010: Cancer Council Queensland: Novel natural antisense ghrelin mRNA transcripts and their role in breast and prostate cancer
- 2011-2013: NHMRC: The function of the natural antisense ghrelin receptor gene (GHSROS) in cancer
- 2014-2016: NHMRC: The ghrelin axis as a target for prostate cancer therapy
- 2014-2016: ARC Discovery:
- The expression, regulation and function of the growth factor ghrelin and its receptor in hormone dependent cancer.
- Identification, structural and functional studies of novel ghrelin receptors.
- Expression, localization, regulation and functional consequences of EphB4 receptor tyrosine kinase in prostate and breast cancers.
Personal details
Positions
- Adjunct Professor
Faculty of Health,
School of Biomedical Sciences - Emeritus Professor
Administrative Division,
Human Resources
Keywords
Endocrinology, Ephs and Ephrins, Ghrelin, Growth Factors, Growth Hormone, Hormone Receptors, Insulin-like Growth Factors, Prostate Cancer
Research field
Biochemistry and cell biology, Clinical sciences, Oncology and carcinogenesis
Field of Research code, Australian and New Zealand Standard Research Classification (ANZSRC), 2020
Qualifications
- Ph.d (Monash University)
- B.Sc (Hons) (Monash University)
Professional memberships and associations
- Medical Advisory Board, Sylvia & Charles Viertel Charitable Foundation
- Endocrine Society (USA)
- Queensland Selection Panel, Australia-America Fulbright Fellowships
- International Growth Hormone/IGF Research Society
- International Proteolysis Society
- Endocrine Society of Australia
- Australasian Society for Biochemistry & Molecular Biology
- Australian Society for Medical Research
Teaching
Teaching discipline: Cell & Molecular Biosciences
Teaching areas
- Hormone Receptors and Signalling
Publications
- Seim, I., Collet, C., Herington, A. & Chopin, L. (2007). Revised Genomic Structure of the Human Ghrelin Gene and Identification of Novel Exons, Alternative Splice Variants and Natural Antisense Transcripts. BMC Genomics, 8(298), 1–16. https://eprints.qut.edu.au/13043
- Gao, J., Collard, R., Bui, L., Herington, A., Nicol, D. & Clements, J. (2007). Kallikrein 4 is a Potential Mediator of Cellular Interactions between Cancer Cells and Osteoblasts in Metastatic Prostate Cancer. The Prostate, 67(4), 348–360. https://eprints.qut.edu.au/43203
- Zhou, S., Zhou, Z., Li, C., Chen, X., Yu, X., Xue, C. & Herington, A. (2007). Identification of Drugs that Interact with Herbs in Drug Development. Drug Discovery Today, 12(15-16), 664–673. https://eprints.qut.edu.au/14827
- Herington, A., (2004). Growth Hormone Binding Proteins. Encyclopedia of Endocrine Diseases, 390–395.
- Shafiei, F., Herington, A. & Lobie, P. (2006). Mechanisms of Signal Transduction Utilized by Growth Hormone. In F. Nyberg (Ed.), The Somatotrophic Axis in Brain Function (pp. 39–49). Elsevier. https://eprints.qut.edu.au/8724
- Yeh, A., Jeffery, P., Duncan, R., Herington, A. & Chopin, L. (2005). Ghrelin and a Novel Preproghrelin Isoform are Highly Expressed in Prostate Cancer and Ghrelin Activates Mitogen-Activated Protein Kinase in Prostate Cancer. Clinical Cancer Research, 11(23), 8295–8303. https://eprints.qut.edu.au/10395
- Jeffery, P., Yeh, A., McNamara, J., Duncan, R., Francis, G., Herington, A. & Chopin, L. (2005). Expression and Function of the Ghrelin Axis, Including a Novel Preproghrelin Isoform, in Human Breast Cancer Tissues and Cell Lines. Endocrine-Related Cancer, 12(4), 839–850. https://eprints.qut.edu.au/22347
- Veveris-Lowe, T., Lawrence, M., Collard, R., Bui, L., Herington, A., Nicol, D. & Clements, J. (2005). Kallikrein 4 (hK4) and Prostate-specific Antigen (PSA) are Associated with the loss of E-cadherin and an Epithelial-mesenchymal Transition (EMT)-like Effect in Prostate Cancer Cells. Endocrine-Related Cancer, 12, 631–643. https://eprints.qut.edu.au/23829
- Jeffery, P., Duncan, R., Yeh, A., Jaskolski, R., Hammond, D., Herington, A. & Chopin, L. (2005). Expression of the Ghrelin Axis in the Mouse: An Exon 4-Deleted Mouse Proghrelin Variant Encodes a Novel C Terminal Peptide. Endocrinology, 146(1), 432–440. https://eprints.qut.edu.au/23050
- Gaytan, F., Morales, C., Barreiro, M., Jeffery, P., Chopin, L., Herington, A., Casanueva, F., Aguilar, E., Dieguez, C. & Tena-Sempere, M. (2005). Expression of Growth Hormone Secretagogue Receptor Type 1a, the Functional Ghrelin Receptor, in Human Ovarian Surface Epithelium Mullerian Duct Derivates and Ovarian Tumors. Journal of Clinical Endocrinology and Metabolism, 90(3), 1798–1804. https://eprints.qut.edu.au/21690
QUT ePrints
For more publications by Adrian, explore their research in QUT ePrints (our digital repository).
Supervision
Completed supervisions (Doctorate)
- A Re-Examination of the Ghrelin and Ghrelin Receptor Genes (2009)
- Localisation of Kallikreins in the Prostate and Association with Prostate Cancer Progression (2006)
- An Investigation into the Role of the Ghrelin Axis in Hormone-Dependent Cancer and Characterisation of a Novel Exon 3-Deleted Preproghrelin Isoform and its Murine Homologue (2005)
- Structural investigations into the relationships of insulin-like growth factors (IGFs) and IGF binding proteins (IGFBPs) with vitronectin (VN) (2005)
- The expression, regulation and function of kallikrein 4 in prostate cancer (2004)
- The Expression of ADAM-9 and -10 in Prostate Cancer and their Regulation by Dihydrotestosterone, Insulin-Like Growth Factor -1 and Epidermal Growth Factor (2003)
Completed supervisions (Masters by Research)
The supervisions listed above are only a selection.