Adjunct Associate Professor
John Bartley
Faculty of Engineering,
School of Mech., Medical & Process Engineering
Biography
Research theme:Environment, Food, Health
Research discipline:
Chemistry
Research areas
Isolation of Biologically Active Natural Products:
Indigenous plants reported to be of medicinal value are under examination to determine that structural nature of any active components Techniques used include HPLC and spectroscopic methods, particularly 2D NMR techniques. Collaboration with the Queensland Institute of Medical Research and with the Forest Research Institute in Dehra Dun, Northern India is involved. Mode of Action of the Anti-tumour Drug
Fotemustine:
The drug Fotemustine, was intended for treatment of brain tumours but high toxicity limits its use to tumours located in limb tissue Preliminary studies suggest that the mode of action is unusual and we are attempting to understand this by examining the reaction with short synthetic oligonucleotides using mass spectrometry techniques.
Drug interaction with triplex DNA:
The drug coralyne binds more strongly to triplex DNA than to duplex DNA. The intimate nature of this interaction is being studied by 2D NMR experiments and will provide essential clues for the design of better ligands with increased sequence specificity and increased relative affinity for triplexes compared to duplexes.
Personal details
Positions
- Adjunct Associate Professor
Faculty of Engineering,
School of Mech., Medical & Process Engineering
Keywords
Chromatography, Mass spectrometry, Natural products, Nuclear magnetic resonance spectroscopy, Organic chemistry, Volatile flavours
Research field
Analytical chemistry, Macromolecular and materials chemistry, Environmental management
Field of Research code, Australian and New Zealand Standard Research Classification (ANZSRC), 2020
Qualifications
- PhD (University of Auckland)
- MSc (Hons) (University of Auckland)
- MSc (University of Auckland)
- BSc (University of Auckland)
Teaching
Teaching discipline:
Chemistry
Publications
- Mendiratta, A., Dayal, R. & Bartley, J. (2007). Two New Apigenin Glycosides from Cephalotaxus Harringtonia var. Harringtonia. Natural Product Communications, 2(12), 1113–1116. https://eprints.qut.edu.au/47402
- Mendiratta, A., Dayal, R. & Bartley, J. (2005). GC/MS Analysis of Essential Oils of Needles and Twigs of Cephalotaxus Harringtonia (Knight ex Forbes) Koch var.Harringtonia. Journal of Essential Oil Research, 17, 308–309. https://eprints.qut.edu.au/21896
- Xu, J., Spittler, D., Bartley, J. & Johnson, R. (2005). Alginic Acid-Silica Hydrogel Coatings for the Protection of Osmotic Distillation membranes Against Wet-Out by Surface-Active Agents. Journal of Membrane Science, 260(1-2), 19–25. https://eprints.qut.edu.au/22579
- Xu, J., Bartley, J. & Johnson, R. (2005). Application of Sodium Alginate-Carrageenan Coatings to PTFE Membranes for Protection Against Wet-Out by Surface-Active Agents. Separation Science and Technology, 40(5), 1067–1081. https://eprints.qut.edu.au/22997
- Xu, J., Lange, S., Bartley, J. & Johnson, R. (2004). Alginate-coated Microporous PTFE Membranes for Use in the Osmotic Distillation of Oily Feeds. Journal of Membrane Science, 240, 81–89. https://eprints.qut.edu.au/23443
- Bartley, J., Huynh, N., Bottle, S., Flitt, H., Notoya, T. & Schweinsberg, P. (2003). Computer Simulation of the Corrosion Inhibition of Copper in Acidic Solution by Alkyl Esters of 5-Carboxybenzotrazole. Corrosion Science, 45(2003), 81–96. https://eprints.qut.edu.au/23620
- Xu, J., Bartley, J. & Johnson, R. (2003). Preparation and Characterization of Alginate Hydrogel Membranes Crosslinked Using a Water Soluble Carbodiimide. Journal of Applied Polymer Science, 90(3), 747–753. https://eprints.qut.edu.au/22639
- Xu, J., Bartley, J. & Johnson, R. (2003). Preparation and Characterization of Alginate-Carrageenan Hydrogel Films Crosslinked Using a Water-Soluble Carbodiimide (WSC). Journal of Membrane Science, 218, 131–146. https://eprints.qut.edu.au/22001
- Smith, C., Bartley, J. & Bottle, S. (2002). Electrospray mass spectrometry of stable iminyl nitroxide and nitronyl nitroxide free radicals. Journal of Mass Spectrometry, 37(9), 897–902. https://eprints.qut.edu.au/22277
- Kaur, S., Dayal, R., Varshney, V. & Bartley, J. (2001). GC-MS Analysis of Essential Oils of Heartwood and Resin of Shorea Robusta. Planta Medica, 883–886. https://eprints.qut.edu.au/23129
QUT ePrints
For more publications by John, explore their research in QUT ePrints (our digital repository).
Supervision
Completed supervisions (Doctorate)
- Spectroscopic Studies of Maya Pigments (2008)
- Chemical and Physical Characterization of Aerosols from the Exhaust Emissions of Motor Vehicles (2007)
- Elucidating the Role of Silicone in the Treatment of Burn Scars: an Essential Step in the Development of Improved Treatment Products (2006)
- Fabrication of Osmotic Distillation Membranes for Feeds Containing Surface-Active Agents (2005)
- Discovery of Anticancer Agents from Indigenous Australian Melicope and Sterculia (2002)
Completed supervisions (Masters by Research)
- The Analysis of Unfired Propellant Particles by Gas Chromatography - Mass Spectrometry: a Forensic Approach (2008)
- A Chemical Investigation of Dendrobium discolour and Senecio madagascariensis (2002)
- Cataract affected infant lens tissue and protein specific mapping of intact tissue analysis by MALDI-TOF/MS (2002)
The supervisions listed above are only a selection.