1342690
Dr Jacqui Mcgovern
Faculty of Health,
School of Biomedical Sciences
Biography
Dr Jacqui McGovern is an interdisciplinary researcher who utilizes biomaterials and tissue engineering techniques to generate in vitro and in vivo models of bone metastatic cancers (e.g. breast and prostate cancer), as well as bone-resident tumours (osteosarcoma and multiple myeloma). She has expertise in 3D tissue models of complex organs, such as skin and bone. Her research aims to use these advanced models to study fundamental interactions between cancer cells and the human bone microenvironment, with the ultimate goal of improving the quality of life for patients affected by metastatic cancer. Dr McGovern has received support from the International Myeloma Foundation, Cancer Australia and Advance Queensland.Personal details
Positions
- Senior Research Fellow
Faculty of Health,
School of Biomedical Sciences
Research field
Biochemistry and cell biology, Biomedical engineering
Field of Research code, Australian and New Zealand Standard Research Classification (ANZSRC), 2020
Qualifications
- PhD (Queensland University of Technology)
- Bachelor of Applied Science (Honours) (Queensland University of Technology)
Professional memberships and associations
- Australian Society for Medical Research (ASMR)
- Tissue Engineering and Regenerative Medicine International Society (TERMIS)
- Australasian Society for Biomaterials and Tissue Engineering (ASBTE)
- Women in Technology (WIT)
- Metastasis Research Society (MRS)
Publications
- Lahr, C., Landgraf, M., Sanchez Herrero, A., Dang, H., Wagner, F., Bas, O., Bray, L., Tran, P., Holzapfel, B., Shafiee, A., Mcgovern, J. & Hutmacher, D. (2020). A 3D-printed biomaterials-based platform to advance established therapy avenues against primary bone cancers. Acta Biomaterialia, 118, 69–82. https://eprints.qut.edu.au/205729
- Sparks, D., Saifzadeh, S., Savi, F., Dlaska, C., Berner, A., Henkel, J., Reichert, J., Wullschleger, M., Ren, J., Cipitria, A., McGovern, J., Steck, R., Wagels, M., Woodruff, M., Schuetz, M. & Hutmacher, D. (2020). A preclinical large-animal model for the assessment of critical-size load-bearing bone defect reconstruction. Nature Protocols, 15(3), 877–924. https://eprints.qut.edu.au/202269
- Sanchez-Herrero, A., Calvo, I., Flandes-Iparraguirre, M., Landgraf, M., Lahr, C., Shafiee, A., Granero-Molto, F., Saez, B., Mazo, M., Paiva, B., Pardo, E., Nicol, A., Prosper, F., Bray, L. & McGovern, J. (2020). Engineering a humanised niche to support human haematopoiesis in mice: Novel opportunities in modelling cancer. Cancers, 12(8). https://eprints.qut.edu.au/203819
- Landgraf, M., Lahr, C., Kaur, I., Shafiee, A., Sanchez-Herrero, A., Janowicz, P., Ravichandran, A., Howard, C., Cifuentes-Rius, A., McGovern, J., Voelcker, N. & Hutmacher, D. (2020). Targeted camptothecin delivery via silicon nanoparticles reduces breast cancer metastasis. Biomaterials, 240. https://eprints.qut.edu.au/203820
- Wagner, F., Holzapfel, B., Martine, L., Mcgovern, J., Lahr, C., Boxberg, M., Prodinger, P., Grassel, S., Loessner, D. & Hutmacher, D. (2019). A humanized bone microenvironment uncovers HIF2 alpha as a latent marker for osteosarcoma. Acta Biomaterialia, 89, 372–381. https://eprints.qut.edu.au/127266
- Landgraf, M., Lahr, C., Sanchez-Herrero, A., Meinert, C., Shokoohmand, A., Pollock, P., Hutmacher, D., Shafiee, A. & McGovern, J. (2019). Humanized bone facilitates prostate cancer metastasis and recapitulates therapeutic effects of zoledronic acid in vivo. Bone Research, 7. https://eprints.qut.edu.au/203778
- Mcgovern, J., Griffin, M. & Hutmacher, D. (2018). Animal models for bone tissue engineering and modelling disease. DMM Disease Models and Mechanisms, 11(4), 1–14.
- Wagner, F., Holzapfel, B., McGovern, J., Shafiee, A., Baldwin, J., Martine, L., Lahr, C., Wunner, F., Friis, T., Bas, O., Boxberg, M., Prodinger, P., Shokoohmand, A., Moi, D., Mazzieri, R., Loessner, D. & Hutmacher, D. (2018). Humanization of bone and bone marrow in an orthotopic site reveals new potential therapeutic targets in osteosarcoma. Biomaterials, 171, 230–246. https://eprints.qut.edu.au/223852
- McGovern, J., Shafiee, A., Wagner, F., Lahr, C., Landgraf, M., Meinert, C., Williams, E., Russell, P., Clements, J., Loessner, D., Holzapfel, B., Risbridger, G. & Hutmacher, D. (2018). Humanization of the prostate microenvironment reduces homing of PC3 prostate cancer cells to human tissue-engineered bone. Cancers, 10(11), 1–15. https://eprints.qut.edu.au/123040
- Shafiee, A., McGovern, J., Lahr, C., Meinert, C., Moi, D., Wagner, F., Landgraf, M., Juan Pardo, E., Mazzieri, R. & Hutmacher, D. (2018). Immune system augmentation via humanization using stem/progenitor cells and bioengineering in a breast cancer model study. International Journal of Cancer, 143(6), 1470–1482. https://eprints.qut.edu.au/223790
QUT ePrints
For more publications by Jacqui, explore their research in QUT ePrints (our digital repository).
Selected research projects
- Title
- Humanized Rat Models - The Next Frontier in Preclinical Osteosarcoma Research
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- CA-APP1181919
- Start year
- 2021
- Keywords
- Osteosarcoma; Tissue Engineering; Bone Defects; Regenerative Medicine; Surgical Procedures
- Title
- Cell and Tissue Engineering Technologies
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- IC190100026
- Start year
- 2019
- Keywords
Projects listed above are funded by Australian Competitive Grants. Projects funded from other sources are not listed due to confidentiality agreements.
Supervision
Current supervisions
- The role of bone marrow fat in advanced prostate cancer using bioengineered humanized models
PhD, Associate Supervisor
Other supervisors: Associate Professor Nathalie Bock, Distinguished Professor Dietmar W Hutmacher, Dr Jennifer Gunter - Tissue engineering a humanized rat model for osteosarcoma research
PhD, Principal Supervisor
Other supervisors: Distinguished Professor Dietmar W Hutmacher - Analysis, quantification and clinical translation of scaffold-based tissue engineering techniques for soft tissue reconstruction
PhD, Associate Supervisor
Other supervisors: Distinguished Professor Dietmar W Hutmacher
Completed supervisions (Doctorate)
- Tissue-Engineering Humanised Bone Sarcoma Models in Rodents - A Preclinical Study Platform For Orthopaedic Research (2021)
- A Humanized Model to Investigate Targeted Therapeutic Strategies Against Cancer Bone Metastasis (2020)
- Convergence of Bioengineering, Orthopaedics and Tumour Biology to Develop and Validate Humanized Rodent Models for Primary Bone Tumour Research (2018)
- In Vitro Characterisation of Melanoma Progression in a Melanoma Skin Equivalent Model (2018)
Completed supervisions (Masters by Research)
Supervision topics
- Targeting a novel adaptive neovascular response of the tumour microenvironment to treat advanced prostate cancer
- Engineering the prostate tumour microenvironment in organ-on-a-chip systems
- Developing a precision oncology workflow for Osteosarcoma treatment
- Engineering bioartificial extracellular tumour microenvironments for Osteosarcoma personalised precision oncology
The supervisions listed above are only a selection.