Adjunct Professor
Louise Bishop
Faculty of Health,
School of Biomedical Sciences
Biography
Research theme: HealthResearch discipline: Biomedical Sciences
Research program: Infectious Diseases
Research areas
Expression Library Immunisation for candidate chlamydial vaccine antigens. Evaluating Novel Vaccine Candidates to prevent sexually transmitted chlamydial infections in women. Identifying effectve adjuvants and delivery systems for novel chlamydial antigens in the guinea pig: C.caviae model of chlamydial genital infection. Protective sequences of chlamydia muridarum were identified as potential vaccine candidates by screening a genomic DNA expression library. (McNeilly et al., 2007) The chlamydial genome was screened for proteins containing epitopes predicted to bind multiple HLA class II molecules. A selection of target proteins were cloned, expressed, and purified (Barker et al., 2008).
Areas of expertise:
- Chlamydia, Streptococcus
- Mucosal Immunology
- Vaccines
- Sexually Transmitted Infectious Diseases,
- Female Reproductive tract
- 2008-2009: Chief Investigator Development of a vaccine for genital chlamydial infections (with Prof. P.Timms and Prof. K. Beagley) National Health and Medical Research Council (NHMRC) Development Grant $ 200,273
- 2009-2011: Chief Investigator Development of a vaccine for genital chlamydial infections (with Prof. P.Timms, Prof. K. Beagley and Prof. K. Ramsey) National Health and Medical Research Council (NHMRC) Project Grant $ 309,250
- 2011-2012 Chief Investigator “A vaccine to reduce rheumatic heart disease and other streptococcal diseases” [awarded to Dr David McMillan (CIA) also with Associate Professor Natkuman Ketheesan (CIC)] National Heart Foundation (NHF) Grant-in-Aid for Research $127,456
- 2012-2014 Chief Investigator - “A polyvalent group A streptococcal vaccine” (awarded to Dr David McMillan (CIA) also with Associate Professor Natkuman Ketheesan (CIB) Dr Martina Sanderson-Smith, (CID), Prof Kadaba Sriprakash. NHMRC Project Grant $585,348
- Expression Library Immunisation for candidate chlamydial vaccine antigens
- Evaluating Novel Vaccine Candidates to prevent sexually transmitted chlamydial infections in women
- Adjuvants for chlamydial vaccines
- Developing vaccines against infections of humans caused by Streptococcus pyogenes (GAS).
Personal details
Positions
- Adjunct Professor
Faculty of Health,
School of Biomedical Sciences
Keywords
Chlamydia trachomatis, Female Reproductive Tract, Mucosal Immunity, Sexually Transmitted Diseases, Vaccines
Research field
Microbiology, Clinical sciences, Medical microbiology
Field of Research code, Australian and New Zealand Standard Research Classification (ANZSRC), 2020
Qualifications
- PhD (La Trobe University)
- BSc(Hons) (La Trobe University)
Professional memberships and associations
Fellow of the Australian Society for Microbiology (FASM)
Teaching
Teaching discipline:
Cell & Molecular Biosciences
Teaching areas:
- Biomedical Sciences
- Microbiology
- Mucosal Immunology
- Medical Mycology
Publications
- Ede, S., Hafner, L., Dunlop, P., Byrne, J. & Will, G. (2012). Photocatalytic disinfection of bacterial pollutants using suspended and immobilized TiO 2 powders. Photochemistry and Photobiology, 88(3), 728–735. https://eprints.qut.edu.au/49651
- Bauer, M., Georgousakis, M., Vu, T., Henningham, A., Hofman, A., Rettel, M., Hafner, L., Sriprakash, K. & McMillan, D. (2012). Evaluation of novel Streptococcus pyogenes vaccine candidates incorporating multiple conserved sequences from the C-repeat region of the M-protein. Vaccine, 30(12), 2197–2205. https://eprints.qut.edu.au/47929
- Hafner, L. & Pelzer, E. (2011). Tubal damage, infertility and tubal ectopic pregnancy: Chlamydia trachomatis and other microbial aetiologies. Ectopic Pregnany - Modern Diagnosis and Management, 13–44. https://eprints.qut.edu.au/43943
- Andrew, D., Hafner, L., Beagley, K. & Timms, P. (2011). Partial protection against chlamydial reproductive tract infection by a recombinant major outer membrane protein/CpG/cholera toxin intranasal vaccine in the guinea pig Chlamydia caviae model. Journal of Reproductive Immunology, 91(1 - 2), 9–16. https://eprints.qut.edu.au/43941
- Carey, A., Cunningham, K., Andrew, D., Hafner, L., Timms, P. & Beagley, K. (2011). A comparison of the effects of a chlamydial vaccine administered during or after a C. muridarum urogenital infection of female mice. Vaccine, 29(38), 6505–6513. https://eprints.qut.edu.au/43942
- Cunningham, K., Carey, A., Hafner, L., Timms, P. & Beagley, K. (2011). Chlamydia muridarum major outer membrane protein-specific antibodies inhibit In vitro infection but enhance pathology in vivo. American Journal of Reproductive Immunology, 65(2), 118–126. https://eprints.qut.edu.au/40829
- Carey, A., Cunningham, K., Hafner, L., Timms, P. & Beagley, K. (2009). Effects of inoculating dose on the kinetics of Chlamydia muridarum genital infection in female mice. Immunology and Cell Biology, 87(4), 337–343. https://eprints.qut.edu.au/28772
- Hafner, L. & McNeilly, C. (2008). Vaccines for chlamydia infections of the female genital tract. Future Microbiology, 3(1), 67–77. https://eprints.qut.edu.au/12509
- Hafner, L., Beagley, K. & Timms, P. (2008). Chlamydia trachomatis infection: host immune responses and potential vaccines. Mucosal Immunology, 1, 116–130. https://eprints.qut.edu.au/12508
- Barker, C., Beagley, K., Hafner, L. & Timms, P. (2008). In silico identification and in vivo analysis of a novel T-cell antigen from Chlamydia, NrdB. Vaccine, 26(10), 1285–1296. https://eprints.qut.edu.au/12290
QUT ePrints
For more publications by Louise, explore their research in QUT ePrints (our digital repository).
Selected research projects
- Title
- A polyvalent group A streptococcal vaccine
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- 1031287
- Start year
- 2012
- Keywords
- Title
- A Vaccine to Reduce Rheumatic Heart Disease and Other Streptococcal Diseases
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- G 10B 5236
- Start year
- 2011
- Keywords
- Title
- Development of a vaccine for genital chlamydia infections: protection against transmission and disease pathology
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- 553026
- Start year
- 2009
- Keywords
- Vaccine Development; Sexually Transmitted Infections; Chlamydia; Immunisation; Mucosal Immunity
Projects listed above are funded by Australian Competitive Grants. Projects funded from other sources are not listed due to confidentiality agreements.
Supervision
Completed supervisions (Doctorate)
- Development of Novel Vaccine Strategies to Prevent Genital Tract Chlamydial Infections (2010)
- Molecular Epidemiology of Respiratory Viruses in a Paediatric Cohort from Indonesia (2010)
- Identification and characterization of novel candidates for a vaccine against chlamydial genital tract infection (2007)
- Identification of Novel Antigens for the Development of a Vaccine to Prevent Sexually Transmitted Chlamydia Infections (2007)
- Infrared and Photocatalytic Studies of Model Bacterial Species for Water Treatment (2007)
- Chlamydia and Chlamydia-like Organisms from Warm and Cold Blooded Animals - a Molecular Approach (2003)