1342149
Adjunct Associate Professor
Michael Doran
Faculty of Health,
School of Biomedical Sciences
Biography
Please see my laboratory's webpage: www.mikedoranlab.comTraining:
- Bachelor of Science (Genetics) - The University of Alberta (Canada)
- Bachelor of Engineering (Chemical) - The University of Alberta (Canada)
- PhD (Biomedical Engineering) - The University of New South Wales (Australia)
Affiliations:
- NHMRC Research Fellow
- Group Leader - Translational Research Institute
- Associate Professor - School of Biomedical Sciences - Queensland University of Technology
- Consultant Scientist - National Institutes of Health, Bethesda
- Honorary Research Fellow - Mater Research Institute - University of Queensland
- Honorary Associate Professor - Australian National Centre for the Public Awareness of Science - Australian National University
Research interests:
- Bioreactor development for large-scale stem or stromal cell expansion.
- Development of novel umbilical cord blood transplantation techniques.
- Development of tissue engineering/stem cell strategies for cartilage defect repair.
- Development of tissue engineering strategies for diabetic foot ulcer repair.
- Design/development of micro-bioreactors for bone marrow stem cell niche recapitulation.
- Development of platforms to study prostate and breast cancer bone metastasis.
- General, including: (1) macroeconomics, (2) the use of multimedia in scientific communication, and (3) the evolution of academia as a business and the associated management challenges.
Personal details
Positions
- Adjunct Associate Professor
Faculty of Health,
School of Biomedical Sciences
Research field
Biochemistry and cell biology, Microbiology, Oncology and carcinogenesis
Field of Research code, Australian and New Zealand Standard Research Classification (ANZSRC), 2020
Qualifications
- PhD (University of New South Wales)
Professional memberships and associations
Please see my laboratory's webpage: http://mikedoranlab.com
Teaching
UNDERGRADUATE TEACHING
- UNSW School of Engineering: Tutored Biochemistry and lectured in Biomechanics.
- UQ School of Engineering: Lectured Cell and Tissue Engineering (Course Captain in 2007).
- QUT School of Biomedical Sciences: Coordinated and lectured LQB248 (Biomedical Skills II, Statistics and scientific communication; 2013 and 2014).
- QUT School of Biomedical Sciences: Coordinated and lectured LQB595 (Cellular Engineering; 2015 and 2016).
Experience
VIDEOS (produced by Michael Kuhn (QUT))
GRANT COMMUNICATION
RESEARCH TRAINING AND INTEGRITY
RESEARCH IMMERSION PROGRAMS:
Our laboratory is heavily involved in research emersion and public teaching. In 2015 A/Prof Mike Doran, Dr. Kathryn Futrega, and Dr. Peter Darben hosted 25 high school students from around Australian in a 1 week intensive research immersion course at the TRI (http://www.di.uq.edu.au/msc-project). Students learned general cell culture techniques, how specifically to grow bone marrow stem/stromal cells, how to differentiate these cells into either bone or fat cells, and how to seed the bone cells onto scaffolds. Our team has since run two related World Science Festival Bioengineering Apprentice Programs.
Below are comments from high school students that completed our SPARQ-ED course:
Read more
- Thank you for Inner Wheel Australia: https://www.youtube.com/watch?v=VrkRfnKa8U0
GRANT COMMUNICATION
- Nature correspondence - http://www.nature.com/nature/journal/v505/n7483/full/505291d.html
- Trends perspective article - http://www.cell.com/trends/biochemical-sciences/abstract/S0968-0004(14)00016-4
- Cell Press/Trends first video abstract: We were invited to submit a video abstract after having promoted the use of video in grant applications. We still have not been awarded an Oscar, but we hope that you benefit from considering the merits of using video in grant applications. https://www.youtube.com/watch?v=vM1sQCcQ8a8
- Interview in Nature Index - https://www.natureindex.com/news-blog/screening-grant-applications
RESEARCH TRAINING AND INTEGRITY
- Michael Doran and William Lott, A Duty of Care, Trends in Biochemical Sciences, 2013 Jan;38(1):1-2. https://doi.org/10.1016/j.tibs.2012.10.002
- Michael Doran,How to survive as a whistle-blower, Nature 532(7599):405-405 https://doi.org/10.1038/nj7599-405a
- Christian, Katherine, Johnstone, Carolyn, Larkins, Jo-ann, Wright, Wendy, & Doran, Michael R., Survey of Australian STEMM Early Career Researchers: job insecurity and questionable research practices are major structural concerns. bioRxiv, 2020 https://doi.org/10.1101/2020.02.19.955328
- Interview, Nature Careers: Australian junior scientists report damaging lack of support at work. https://www.nature.com/articles/d41586-020-00687-0
- Interview, Nature Index: Here’s why so many young researchers want to quit – in five graphs. https://www.natureindex.com/news-blog/heres-why-so-many-young-researchers-want-to-quit-in-five-graphs
RESEARCH IMMERSION PROGRAMS:
Our laboratory is heavily involved in research emersion and public teaching. In 2015 A/Prof Mike Doran, Dr. Kathryn Futrega, and Dr. Peter Darben hosted 25 high school students from around Australian in a 1 week intensive research immersion course at the TRI (http://www.di.uq.edu.au/msc-project). Students learned general cell culture techniques, how specifically to grow bone marrow stem/stromal cells, how to differentiate these cells into either bone or fat cells, and how to seed the bone cells onto scaffolds. Our team has since run two related World Science Festival Bioengineering Apprentice Programs.
Below are comments from high school students that completed our SPARQ-ED course:
- “Interactions with other students with the same interests -> self-explanatory. Learning to operate scientific equipment. Listening to experts talk because I found what they said extremely interesting” – Male Student
- “I really enjoyed the physical lab work. It gave me great insight into research and helped me decide that I would like to go into research in the future” – Female Student
- “The exposure to the labs and experience of what scientists do” – Female Student
- “Understanding the concepts as a whole, and seeing all the elements some together when the 3D scaffold was seeded with cells” – Male Student
- “All the practical activities were very rewarding because I did not know the procedures beforehand” – Male Student.
- “I found the lab work rewarding as it was useful to my future and learnt many new techniques. I found the lectures useful as they will help me with school work” – Female Student
- “The best parts of the program was the lab activities because I find it easier to understand the concepts” – Male Student
- “I enjoyed the experience itself, however the most rewarding experience I had was developing new friendships” – Male Student
- “I enjoyed the migration / wound healing experiment because we got to decide which drinks to use and it was therefore more like we were doing the experiment rather than just following instructions (which was fine) – it would be nice to have more experiments like that” – Female Student
- “The people I met and the immersion into very hands-on work, We met many scientists that helped us understand what a career in research Science will look like” – Female Student
- “Experience in professional lab. Advanced scientific topics not generally covered in school. Talking to working scientists” – Female Student
- “The overall lab work and seminars were very rewarding as they showed the process real researchers undertake” – Male Student
- “Preparing solutions by following procedures outlined in manual – procedures were clear and this gave a sense of independency. Seeing successful cell growth was rewarding J” – Female Student
- “The migration and expansion assay were particularly rewarding. I understood these concepts the most and found the results very interesting. The application of this kind of research also was very interesting and could be related to on a practical level. It puts the work that is being done into perspective and is really very relevant. I also think the presentation will prove to be very rewarding, as it will be relevant and will therefore help students when writing EEI reports in class. Seeing the facilities was very rewarding and a great opportunity. This week has been great” – Female Student
- “The lectures before each part of the project were very useful as they allowed me to understand and explain what I was doing” – Male Student
- “Being able to see results, do real lab work” – Male Student
- “I made a lot of friends and learnt many relevant scientific and cellular concepts” – Male Student
- “The hands-on research experiments because I have never experiences research in an actual research facility. It gave me an insight on the work researchers do and the equipment they have available to them” – Female Student
- “Laboratory work -> hands on approach, realistic experience of what to expect in a biomedical science career. Ability to view, engage with and use high-tech equipment. Friday lunch. Being able to discuss with the tutors assisting and getting their insight on their careers, etc. being in the beautiful building J” – Female Student
- “The 3D printing was interesting and showed a technology I hadn’t seen much of before. Plus insights into possible future applications. Also getting to apply techniques and use the equipment and machines available in the TRI and would never be seen in a school course” – Female Student
- “I found the 3D printing particularly interesting, however the thing I found most rewarding as a whole was just being allowed to use the equipment, and gather an understanding of what happens in scientific research facilities” – Female Student
- “Learning how to use the equipment in the lab and being able to see the upstairs working spaces. Also talking to all of the scientists about what they do and the university courses they completed to get where they are today” – Female Student
- “Presenting at the end of the program -> needed us to coherently sum up and condense a lot of information and data, which improved understanding of concepts. As well as, of course, the lab work and talks about the topics and conducting routine lab work” – Female Student
- “The socialising parts – where you had open conversations” – Male Student
Publications
- Futrega, K., Palmer, J., Kinney, M., Lott, B., Ungrin, M., Zandstra, P. & Doran, M. (2015). The microwell-mesh: A novel device and protocol for the high throughput manufacturing of cartilage microtissues. Biomaterials, 62, 1–12. https://eprints.qut.edu.au/85865
- Futrega, K., King, M., Lott, B. & Doran, M. (2014). Treating the whole not the hole: necessary coupling of technologies for diabetic foot ulcer treatment. Trends in Molecular Medicine, 20(3), 137–142. https://eprints.qut.edu.au/68193
- Doran, M., Lott, B. & Doran, S. (2014). Multimedia: a necessary step in the evolution of research funding applications. Trends in Biochemical Sciences, 39(4), 151–153. https://eprints.qut.edu.au/69944
- Doran, M., Lott, B. & Doran, S. (2014). Communication: Use multimedia in grant applications [Correspondence]. Nature: international weekly journal of science, 505(7483), 291. https://eprints.qut.edu.au/68707
- Lott, B. & Doran, M. (2013). Do RNA viruses require genome cyclisation for replication? Trends in Biochemical Sciences, 38(7), 350–355. https://eprints.qut.edu.au/60782
- Doran, M. & Lott, W. (2013). A duty of care. Trends in Biochemical Sciences, 38(1), 1–2. https://eprints.qut.edu.au/55612
- Cook, M., Futrega, K., Osiecki, M., Kabiri Renani, M., Kul, B., Rice, A., Atkinson, K., Brooke, G. & Doran, M. (2012). Micromarrows - 3D co-culture of haematopoietic stem cells and mesenchymal stromal cells. Tissue Engineering, Part C: Methods, 18(5), 319–328. https://eprints.qut.edu.au/55609
- Osiecki, M., Ghanavi, P., Atkinson, K., Nielsen, L. & Doran, M. (2010). The ascorbic acid paradox. Biochemical and Biophysical Research Communications, 400(4), 466–470. https://eprints.qut.edu.au/45529
- Gray, P., Cooper-White, J., Doran, M., Frith, J., Prowse, A., Fitzpatrick, J., Wolvetang, E. & Munro, T. (2010). Defined high protein content surfaces for stem cell culture. Biomaterials, 31(19), 5137–5142. https://eprints.qut.edu.au/45018
- Markway, B., Tan, G., Brooke, G., Hudson, J., Cooper-White, J. & Doran, M. (2010). Enhanced chondrogenic differentiation of human bone marrow-derived mesenchymal stem cells in low oxygen environment micropellet cultures. Cell Transplantation, 19(1), 29–42. https://eprints.qut.edu.au/44497
QUT ePrints
For more publications by Michael, explore their research in QUT ePrints (our digital repository).
Selected research projects
- Title
- Bridging the fields of cartilage, bone marrow and cancer research
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- 1130013
- Start year
- 2017
- Keywords
- Stem Cell Biology; Osteoarthritis; Prostate Cancer; Bone Marrow Transplantation; Biomedical Engineering
- Title
- The Microniche: A Novel In-vitro and In-vivo Prostate Cancer Model System
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- 1108043
- Start year
- 2016
- Keywords
- Prostate Cancer; Metastatic Cancer; Bone Marrow; Stem Cell Biology; Hormone-refractory Prostate Cancer
- Title
- Coupling an injectable gel and MSC microtissues to enhance cartilage repair
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- 1083857
- Start year
- 2015
- Keywords
- cartilage; regenerative medicine; stem cell therapy; biomedical engineering; biomaterials
- Title
- Engineering an Osteochondral Tissue for Cartilage Defect Repair
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- 1060340
- Start year
- 2014
- Keywords
- Biomedical Engineering; Stem Cells; Cartilage; Osteoarthritis; Tissue Engineering
- Title
- Mimicking the HSC Niche and Enabling HSC Self-renewal In Vitro
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- CA-APP1060928
- Start year
- 2014
- Keywords
- Regenerative Medicine; Stem Cells; Stem Cell Therapy; Haematopoietic Stem Cells; Haematopoiesis; Bone Marrow Stroma; Bone Marrow
- Title
- Engineering a High-Throughput Prostate Cancer Stem Cell Niche Mimic
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- NCG 3212
- Start year
- 2013
- Keywords
- Bioengineering; Cancer; Stem Cells; Therapy
- Title
- Innovations in Diabetic Foot Ulcer (DFU) Wound Care
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- 1048385
- Start year
- 2013
- Keywords
- biotechnology; stem cell therapy; ulceration; biomaterials; wound healing
- Title
- Taking the Limp out of Cartilage Repair
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- 631629
- Start year
- 2010
- Keywords
- Biomedical Engineering; Catilage; Stem Cells; Regenerative Medicine
Projects listed above are funded by Australian Competitive Grants. Projects funded from other sources are not listed due to confidentiality agreements.