QUT - Academic profiles - Adjunct Associate Professor Miguel Enrique Rentería

Biography

I am a genetic epidemiologist specialising in the genetics of neurodegenerative diseases, with a particular focus on Parkinson’s disease, chronic pain, and other age-related conditions. I lead a dynamic team of scientists dedicated to understanding how genetic and environmental factors influence neurodegeneration, brain health, and related health outcomes. My research is interdisciplinary, integrating advanced statistical genetics, bioinformatics, and data science to unravel disease mechanisms, improve patient stratification, and identify potential therapeutic targets.

In 2020, I founded the Australian Parkinson’s Genetics Study (APGS), now the largest Parkinson’s cohort in Australia with over 10,000 participants. This landmark study has positioned Australia as a key contributor to global Parkinson’s genetics research. I am also actively involved in the Global Parkinson’s Genetics Program (GP2), where I contribute to large-scale data analysis and work within the underrepresented populations working group to enhance diversity in genetic research worldwide.

Committed to training the next generation of researchers, I have supervised over 16 students, including several PhD candidates who have gone on to successful careers in academia and industry. Two of my recent PhD graduates received the Outstanding Thesis Award, and another received the AIPS Florey Next Generation Award.

I have published consistently in prominent journals, including Nature, Nature Genetics, Nature Communications, BRAIN, Biological Psychiatry, and SLEEP. To date, I have authored over 100 academic articles, which have been widely cited, and I have secured competitive funding from NHMRC, MRFF, The Michael J. Fox Foundation for Parkinson’s Research, Shake It Up Australia Foundation, the US National Institutes of Health, and the Alzheimer’s Association. My work has been recognised with several prestigious awards, including the 2023 Al & Val Rosenstrauss Fellowship from the Rebecca L Cooper Medical Research Foundation, the 2021 Enrico Greppi International Migraine Research Award, and the 2024 Adele Green Emerging Leader Award from QIMR Berghofer Medical Research Institute. I am also a Global Atlantic Fellow for Equity in Brain Health, a program by the University of California San Francisco and Trinity College Dublin, which supports my commitment to promoting brain health equity worldwide.

miguelenrique.renteria@qut.edu.au

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Personal details

Positions

Adjunct Associate Professor
Faculty of Health,
School of Biomedical Sciences

Research field

Medical biochemistry and metabolomics, Medical microbiology

Field of Research code, Australian and New Zealand Standard Research Classification (ANZSRC), 2020

Professional memberships and associations

American Society for Human Genetics
Society for Biological Psychiatry
International Society for Psychiatric Genetics
The Movement Disorder Society

Publications

QUT ePrints

For more publications by Miguel Enrique, explore their research in QUT ePrints (our digital repository).

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2023

Jayarathna, D., Renteria, M. E., Batra, J. & Gandhi, N. S. (2023). Integrative competing endogenous RNA network analyses identify novel lncRNA and genes implicated in metastatic breast cancer. Scientific Reports, Article 2423, 13(1), 2423. https://eprints.qut.edu.au/238018
Gomez, L., Diaz-Torres, S., Colodro-Conde, L., Garcia-Marin, L. M., Yap, C. X., Byrne, E. M., Yengo, L., Lind, P. A., Wray, N. R., Medland, S. E., Hickie, I. B., Lupton, M. K., Rentería, M. E., Martin, N. G. & Campos, A. I. (2023). Phenotypic and genetic factors associated with donation of DNA and consent to record linkage for prescription history in the Australian Genetics of Depression Study. European Archives of Psychiatry and Clinical Neuroscience, 273(6), 1359–1368. https://eprints.qut.edu.au/240152
Campos, A. I., Ingold, N., Huang, Y., Mitchell, B. L., Kho, P. F., Han, X., García-Marín, L. M., Ong, J. S., Law, M. H., Yokoyama, J. S., Martin, N. G., Dong, X., Cuellar-Partida, G., MacGregor, S., Aslibekyan, S., Rentería, M. E. & other (2023). Discovery of genomic loci associated with sleep apnea risk through multi-trait GWAS analysis with snoring. Sleep, Article zsac308, 46(3). https://eprints.qut.edu.au/243475
Han, X., Gharahkhani, P., Hamel, A. R., Ong, J. S., Renteria, M. E., Mehta, P., Dong, X., Pasutto, F., Hammond, C., Young, T. L., Hysi, P., Lotery, A. J., Jorgenson, E., Choquet, H., Hauser, M., Cooke Bailey, J. N., Nakazawa, T., Akiyama, M., Shiga, Y., Fuller, Z. L., Wang, X., Hewitt, A. W., Craig, J. E., Pasquale, L. R., Mackey, D. A., Wiggs, J. L., Khawaja, A. P., Segrè, A. V., MacGregor, S. & other (2023). Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci. Nature Genetics, 55(7), 1116–1125. https://eprints.qut.edu.au/252749
Garcia-Marin, L. M., Mulcahy, A., Byrne, E. M., Medland, S. E., Wray, N. R., Chafota, F., Lind, P. A., Martin, N. G., Hickie, I. B., Renteria, M. E. & Campos, A. I. (2023). Discontinuation of antidepressant treatment: a retrospective cohort study on more than 20,000 participants. Annals of General Psychiatry, Article 49, 22. https://eprints.qut.edu.au/253763

2022

Jayarathna, D., Renteria, M. E., Batra, J. & Gandhi, N. S. (2022). A supervised machine learning approach identifies gene-regulating factor-mediated competing endogenous RNA networks in hormone-dependent cancers. Journal of Cellular Biochemistry, 123(8), 1394–1408. https://eprints.qut.edu.au/232629
Mitchell, B. L., Diaz-Torres, S., Bivol, S., Cuellar-Partida, G., Gerring, Z. F., Martin, N. G., Medland, S. E., Grasby, K. L., Nyholt, D. R., Rentería, M. E. & other (2022). Elucidating the relationship between migraine risk and brain structure using genetic data. Brain, 145(9), 3214–3224. https://eprints.qut.edu.au/233593
Jayarathna, D., Renteria, M. E., Kho, P. F., Batra, J. & Gandhi, N. S. (2022). Dehydroepiandrosterone Sulfate and Colorectal Cancer Risk: A Mendelian Randomization Analysis. Twin Research and Human Genetics, 25(4-5), 180–186. https://eprints.qut.edu.au/234032
Mitchell, B. L., Hansell, N. K., McAloney, K., Martin, N. G., Wright, M. J., Renteria, M. E. & Grasby, K. L. (2022). Polygenic influences associated with adolescent cognitive skills. Intelligence, Article 101680, 94. https://eprints.qut.edu.au/237394
Pain, O., Hodgson, K., Trubetskoy, V., Ripke, S., Marshe, V. S., Adams, M. J., Byrne, E. M., Campos, A. I., Carrillo-Roa, T., Cattaneo, A., Als, T. D., Souery, D., Dernovsek, M. Z., Fabbri, C., Hayward, C., Henigsberg, N., Hauser, J., Kennedy, J. L., Lenze, E. J., Lewis, G., Müller, D. J., Martin, N. G., Mulsant, B. H., Mors, O., Perroud, N., Porteous, D. J., Rentería, M. E., Reynolds, C. F., Rietschel, M., Uher, R., Wigmore, E. M., Maier, W., Wray, N. R., Aitchison, K. J., Arolt, V., Baune, B. T., Biernacka, J. M., Bondolfi, G., Domschke, K., Kato, M., Li, Q. S., Liu, Y. L., Serretti, A., Tsai, S. J., Turecki, G., Weinshilboum, R., Kasper, S., Zohar, J., Montgomery, S., Albani, D., Forloni, G., Ferentinos, P., Rujescu, D., Mendlewicz, J., Mattheisen, M., Trzaskowski, M., Abdellaoui, A., Agerbo, E., Air, T. M., Andlauer, T. F. M., Bacanu, S. A., Bækvad-Hansen, M., Beekman, A. T. F., Bigdeli, T. B., Binder, E. B., Bryois, J., Buttenschøn, H. N., Bybjerg-Grauholm, J., Cai, N., Castelao, E., Christensen, J. H., Clarke, T. K., Coleman, J. R. I., Colodro-Conde, L., Couvy-Duchesne, B., Craddock, N., Crawford, G. E., Davies, G., Deary, I. J., Degenhardt, F., Derks, E. M., Direk, N., Dolan, C. V., Dunn, E. C., Eley, T. C., Escott-Price, V., Hassan Kiadeh, F. F., Finucane, H. K., Foo, J. C., Forstner, A. J., Frank, J., Gaspar, H. A., Gill, M., Goes, F. S., Gordon, S. D., Grove, J., Hall, L. S., Hansen, C. S., Hansen, T. F., Herms, S., Hickie, I. B., Hoffmann, P., Homuth, G., Horn, C., Hottenga, J. J., Hougaard, D. M., Howard, D. M., Ising, M., Jansen, R., Jones, I., Jones, L. A., Jorgenson, E., Knowles, J. A., Kohane, I. S., Kraft, J., Kretzschmar, W. W., Kutalik, Z., Li, Y., Lind, P. A., MacIntyre, D. J., MacKinnon, D. F., Maier, R. M., Marchini, J., Mbarek, H., McGrath, P., McGuffin, P., Medland, S. E., Mehta, D., Middeldorp, C. M., Mihailov, E., Milaneschi, Y., Milani, L., Mondimore, F. M., Montgomery, G. W., Mostafavi, S., Mullins, N., Nauck, M., Ng, B., Nivard, M. G., Nyholt, D. R., O'Reilly, P. F., Oskarsson, H., Owen, M. J., Painter, J. N., Pedersen, C. B., Pedersen, M. G., Peterson, R. E., Peyrot, W. J., Pistis, G., Posthuma, D., Quiroz, J. A., Qvist, P., Rice, J. P., Riley, B. P., Rivera, M., Mirza, S. S., Schoevers, R., Schulte, E. C., Shen, L., Shi, J., Shyn, S. I., Sigurdsson, E., Sinnamon, G. C. B., Smit, J. H., Smith, D. J., Stefansson, H., Steinberg, S., Streit, F., Strohmaier, J., Tansey, K. E., Teismann, H., Teumer, A., Thompson, W., Thomson, P. A., Thorgeirsson, T. E., Traylor, M., Treutlein, J., Uitterlinden, A. G., Umbricht, D., Van der Auwera, S., van Hemert, A. M., Viktorin, A., Visscher, P. M., Wang, Y., Webb, B. T., Weinsheimer, S. M., Wellmann, J., Willemsen, G., Witt, S. H., Wu, Y., Xi, H. S., Yang, J., Zhang, F., Berger, K., Boomsma, D. I., Cichon, S., Dannlowski, U., de Geus, E. J. C., DePaulo, J. R., Domenici, E., Esko, T., Grabe, H. J., Hamilton, S. P., Heath, A. C., Kendler, K. S., Kloiber, S., Lucae, S., Madden, P. A. F., Magnusson, P. K., McIntosh, A. M., Metspalu, A., Mortensen, P. B., Müller-Myhsok, B., Nordentoft, M., Nöthen, M. M., O'Donovan, M. C., Paciga, S. A., Pedersen, N. L., Potash, J. B., Perlis, R. H., Penninx, B. W. J. H., Preisig, M., Schaefer, C., Schulze, T. G., Smoller, J. W., Stefansson, K., Tiemeier, H., Völzke, H., Weissman, M. M., Werge, T., Lewis, C. M., Levinson, D. F., Breen, G., Børglum, A. D., Sullivan, P. F. & other (2022). Identifying the Common Genetic Basis of Antidepressant Response. Biological Psychiatry Global Open Science, 2(2), 115–126. https://eprints.qut.edu.au/238891
Mullins, N., Kang, J. E., Campos, A. I., Coleman, J. R. I., Edwards, A. C., Galfalvy, H., Levey, D. F., Lori, A., Shabalin, A., Starnawska, A., Su, M. H., Watson, H. J., Adams, M. J., Awasthi, S., Gandal, M., Hafferty, J. D., Hishimoto, A., Kim, M., Okazaki, S., Otsuka, I., Ripke, S., Ware, E. B., Bergen, A. W., Berrettini, W. H., Bohus, M., Brandt, H., Chang, X., Chen, W. J., Chen, H. C., Crawford, S., Crow, S., DiBlasi, E., Duriez, P., Fernández-Aranda, F., Fichter, M. M., Gallinger, S., Glatt, S. J., Gorwood, P., Guo, Y., Hakonarson, H., Halmi, K. A., Hwu, H. G., Jain, S., Jamain, S., Jiménez-Murcia, S., Johnson, C., Kaplan, A. S., Kaye, W. H., Keel, P. K., Kennedy, J. L., Klump, K. L., Li, D., Liao, S. C., Lieb, K., Lilenfeld, L., Liu, C. M., Magistretti, P. J., Marshall, C. R., Mitchell, J. E., Monson, E. T., Myers, R. M., Pinto, D., Powers, A., Ramoz, N., Roepke, S., Rozanov, V., Scherer, S. W., Schmahl, C., Sokolowski, M., Strober, M., Thornton, L. M., Treasure, J., Tsuang, M. T., Witt, S. H., Woodside, D. B., Yilmaz, Z., Zillich, L., Adolfsson, R., Agartz, I., Air, T. M., Alda, M., Alfredsson, L., Andreassen, O. A., Anjorin, A., Appadurai, V., Soler Artigas, M., Van der Auwera, S., Azevedo, M. H., Bass, N., Bau, C. H. D., Baune, B. T., Bellivier, F., Berger, K., Biernacka, J. M., Bigdeli, T. B., Binder, E. B., Boehnke, M., Boks, M. P., Bosch, R., Braff, D. L., Bryant, R., Budde, M., Byrne, E. M., Cahn, W., Casas, M., Castelao, E., Cervilla, J. A., Chaumette, B., Cichon, S., Corvin, A., Craddock, N., Craig, D., Degenhardt, F., Djurovic, S., Edenberg, H. J., Fanous, A. H., Foo, J. C., Forstner, A. J., Frye, M., Fullerton, J. M., Gatt, J. M., Gejman, P. V., Giegling, I., Grabe, H. J., Green, M. J., Grevet, E. H., Grigoroiu-Serbanescu, M., Gutierrez, B., Guzman-Parra, J., Hamilton, S. P., Hamshere, M. L., Hartmann, A., Hauser, J., Heilmann-Heimbach, S., Hoffmann, P., Ising, M., Jones, I., Jones, L. A., Jonsson, L., Kahn, R. S., Kelsoe, J. R., Kendler, K. S., Kloiber, S., Koenen, K. C., Kogevinas, M., Konte, B., Krebs, M. O., Landén, M., Lawrence, J., Leboyer, M., Lee, P. H., Levinson, D. F., Liao, C., Lissowska, J., Lucae, S., Mayoral, F., McElroy, S. L., McGrath, P., McGuffin, P., McQuillin, A., Medland, S. E., Mehta, D., Melle, I., Milaneschi, Y., Mitchell, P. B., Molina, E., Morken, G., Mortensen, P. B., Müller-Myhsok, B., Nievergelt, C., Nimgaonkar, V., Nöthen, M. M., O'Donovan, M. C., Ophoff, R. A., Owen, M. J., Pato, C., Pato, M. T., Penninx, B. W. J. H., Pimm, J., Pistis, G., Potash, J. B., Power, R. A., Preisig, M., Quested, D., Ramos-Quiroga, J. A., Reif, A., Ribasés, M., Richarte, V., Rietschel, M., Rivera, M., Roberts, A., Roberts, G., Rouleau, G. A., Rovaris, D. L., Rujescu, D., Sánchez-Mora, C., Sanders, A. R., Schofield, P. R., Schulze, T. G., Scott, L. J., Serretti, A., Shi, J., Shyn, S. I., Sirignano, L., Sklar, P., Smeland, O. B., Smoller, J. W., Sonuga-Barke, E. J. S., Spalletta, G., Strauss, J. S., Świątkowska, B., Trzaskowski, M., Turecki, G., Vilar-Ribó, L., Vincent, J. B., Völzke, H., Walters, J. T. R., Shannon Weickert, C., Weickert, T. W., Weissman, M. M., Williams, L. M., Colodro-Conde, L., Derks, E. M., Gill, M., Gordon, S., Howard, D. M., Lind, P. A., Maier, W., Nyholt, D. R., Martin, N. G., Rice, J. P., Smith, D. J., Visscher, P. M., Sullivan, P. F., Qiao, Z., Bauer, M., Johnson, J. S., Young, H., Pearson, J. F., Hudson, J. I., Kennedy, M. A., Kirk, K. M., Whiteman, D. C., O'Donnell, C. J., Sun, Y., Wilson, P., Cohen, D., Rentería, M. E. & other (2022). Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors. Biological Psychiatry, 91(3), 313–327. https://eprints.qut.edu.au/238890
Campos, A. I., Byrne, E. M., Mitchell, B. L., Wray, N. R., Lind, P. A., Licinio, J., Medland, S. E., Martin, N. G., Hickie, I. B. & Rentería, M. E. (2022). Impact of CYP2C19 metaboliser status on SSRI response: a retrospective study of 9500 participants of the Australian Genetics of Depression Study. Pharmacogenomics Journal, 22(2), 130–135. https://eprints.qut.edu.au/240473
Mitchell, B. L., Saklatvala, J. R., Dand, N., Hagenbeek, F. A., Li, X., Min, J. L., Thomas, L., Bartels, M., Jan Hottenga, J., Lupton, M. K., Boomsma, D. I., Dong, X., Hveem, K., Løset, M., Martin, N. G., Barker, J. N., Han, J., Smith, C. H., Rentería, M. E. & Simpson, M. A. (2022). Genome-wide association meta-analysis identifies 29 new acne susceptibility loci. Nature Communications, Article 702, 13. https://eprints.qut.edu.au/240488
Rabinowitz, J. A., Campos, A. I., Ong, J. S., Garcia-Marin, L. M., Alcauter, S., Mitchell, B. L., Grasby, K. L., Cuéllar-Partida, G., Gillespie, N. A., Huhn, A. S., Martin, N. G., Thompson, P. M., Medland, S. E., Maher, B. S. & Renteria, M. E. (2022). Shared Genetic Etiology between Cortical Brain Morphology and Tobacco, Alcohol, and Cannabis Use. Cerebral Cortex, 32(4), 796–807. https://eprints.qut.edu.au/241142
Bivol, S., Mellick, G. D., Gratten, J., Parker, R., Mulcahy, A., Mosley, P. E., Poortvliet, P. C., Campos, A. I., Mitchell, B. L., Garcia-Marin, L. M., Cross, S., Ferguson, M., Lind, P. A., Loesch, D. Z., Visscher, P. M., Medland, S. E., Scherzer, C. R., Martin, N. G. & Rentería, M. E. (2022). Australian Parkinson's Genetics Study (APGS): Pilot (n=1532). BMJ Open, Article e052032, 12(2). https://eprints.qut.edu.au/241416

A complete list of publications is available at: https://www.qut.edu.au/about/our-people/academic-profiles/miguelenrique.renteria

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Adjunct Associate ProfessorMiguel Enrique Rentería