Adjunct Professor
Yin Xiao
Faculty of Engineering,
School of Mech., Medical & Process Engineering
Biography
Professor Yin Xiao is a Distinguished Professor in Medicine and Dentistry at Griffith University. He is also an Adjunct Professor at Queensland University of Technology (QUT) and an Honorary Professor at the University of Queensland. He is the Director of the Australia-China Centre for Tissue Engineering and Regenerative Medicine and a group leader in regenerative medicine with a special interest in bone and tissue engineering. He obtained his BDSc and MDSc from Wuhan University (Hubei Medical University), China, with more than 10 years of clinical experience. In 2000, he graduated with a Ph.D. from the School of Dentistry at the University of Queensland (UQ), Australia, and worked as a research officer there for two years following his graduation. This was followed by an NHMRC Peter Doherty Fellowship at the School of Life Sciences at the QUT. In 2004 he was awarded an NHMRC Visiting Fellowship for 6 months at the Bone Tissue Engineering Centre at the University of Carnegie Mellon, PA, USA. During this period (2003–2007) he was also appointed an Honorary Research Advisor to the School of Dentistry, UQ. He established a bone and tissue engineering laboratory at QUT and was appointed as a tenured Associate Professor in 2005 at QUT. In 2012 he was appointed a Full Professor in the Department of Medical Engineering at QUT and Chair of the Bone and Tissue Engineering program.Personal details
Positions
- Adjunct Professor
Faculty of Engineering,
School of Mech., Medical & Process Engineering
Keywords
Biomaterials, Bone, Bone marrow stem cell, Dentistry, Osteoarthritis, Osteoblast, Stem cell, Tissue engineering
Research field
Biochemistry and cell biology, Clinical sciences, Medical biotechnology
Field of Research code, Australian and New Zealand Standard Research Classification (ANZSRC), 2020
Qualifications
- PhD (University of Queensland)
Professional memberships and associations
- Australian and New Zealand Orthopaedic Research Society
- Australasian Society for Biomaterials and Tissue Engineering
- Tissue Engineering and Regenerative Medicine International Society
- Australian Society for Medical Research
- International Association for Dental Research
- International Chinese Hard Tissue Society
Teaching
Teaching areas
- Medical Engineering
- Biomaterials
- Bone Biology.
Publications
- Chen, Z., Wu, C., Gu, W., Klein, T., Crawford, R. & Xiao, Y. (2014). Osteogenic differentiation of bone marrow MSCs by beta-tricalcium phosphate stimulating macrophages via BMP2 signalling pathway. Biomaterials, 35(5), 1507–1518. https://eprints.qut.edu.au/63976
- Truong, N., Gu, W., Prasadam, I., Jia, Z., Crawford, R., Xiao, Y. & Monteiro, M. (2013). An influenza virus-inspired polymer system for the timed release of siRNA. Nature Communications, 4, 1–7. https://eprints.qut.edu.au/59413
- Prasadam, I., Mao, X., Shi, W., Crawford, R. & Xiao, Y. (2013). Combination of MEK-ERK inhibitor and hyaluronic acid has a synergistic effect on anti-hypertrophic and pro-chondrogenic activities in osteoarthritis treatment. Journal of Molecular Medicine, 91(3), 369–380. https://eprints.qut.edu.au/53500
- Wu, C., Zhou, Y., Xu, M., Han, P., Chen, L., Chang, J. & Xiao, Y. (2013). Copper-containing mesoporous bioactive glass scaffolds with multifunctional properties of angiogenesis capacity, osteostimulation and antibacterial activity. Biomaterials, 34(2), 422–433. https://eprints.qut.edu.au/53873
- Zhou, Y., Wu, C., Zhang, X., Han, P. & Xiao, Y. (2013). The ionic products from bredigite bioceramics induced cementogenic differentiation of periodontal ligament cells via activation of the Wnt/Beta-catenin signalling pathway. Journal of Materials Chemistry B, 1(27), 3380–3389. https://eprints.qut.edu.au/60006
- Wu, C., Zhou, Y., Fan, W., Han, P., Chang, J., Yuen, J., Zhang, M. & Xiao, Y. (2012). Hypoxia-mimicking mesoporous bioactive glass scaffolds with controllable cobalt ion release for bone tissue engineering. Biomaterials, 33(7), 2076–2085. https://eprints.qut.edu.au/47336
- Tumkur Jaiprakash, A., Prasadam, I., Feng, J., Liu, Y., Crawford, R. & Xiao, Y. (2012). Phenotypic characterization of osteoarthritic osteocytes from the sclerotic zones: A possible pathological role in subchondral bone sclerosis. International Journal of Biological Sciences, 8(3), 406–417. https://eprints.qut.edu.au/49359
- Han, P., Wu, C., Chang, J. & Xiao, Y. (2012). The cementogenic differentiation of periodontal ligament cells via the activation of Wnt/Beta-catenin signalling pathway by Li+ ions released from bioactive scaffolds. Biomaterials, 33(27), 6370–6379. https://eprints.qut.edu.au/50849
- Prasadam, I., van Gennip, S., Friis, T., Shi, W., Crawford, R. & Xiao, Y. (2010). ERK-1/2 and p38 in the regulation of hypertrophic changes of normal articular cartilage Chondrocytes induced by osteoarthritic subchondral osteoarthritica subchondral osteoblasts. Arthritis and Rheumatism, 62(5), 1349–1360. https://eprints.qut.edu.au/34478
- Fan, W., Crawford, R. & Xiao, Y. (2010). Enhancing in vivo vascularized bone formation by cobalt chloride-treated bone marrow stromal cells in a tissue engineered periosteum model. Biomaterials, 31(13), 3580–3589. https://eprints.qut.edu.au/31500
QUT ePrints
For more publications by Yin, explore their research in QUT ePrints (our digital repository).
Selected research projects
- Title
- A Multiscale Modelling Framework for Mechanical Properties of ECM
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- DP150100828
- Start year
- 2015
- Keywords
- Hierarchical multiscale modelling; Mechanical behaviour; Extracellular Matrix
- Title
- Coupling an injectable gel and MSC microtissues to enhance cartilage repair
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- 1083857
- Start year
- 2015
- Keywords
- cartilage; regenerative medicine; stem cell therapy; biomedical engineering; biomaterials
- Title
- Hypoxia-mimicking Bio-scaffold for Skeleton Regeneration
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- DP120103697
- Start year
- 2012
- Keywords
- Bone Substitute; Hypoxia; Scaffolds; Regenerative Medicine
- Title
- MAPK/ERK pathway in osteoarthritis
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- 1032738
- Start year
- 2012
- Keywords
- osteoarthritis; pathogenesis; cell signalling; kinases; animal model
- Title
- Cementogenesis and New Periodontal Attachment Formation Using Cell Sheets
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- 597455
- Start year
- 2010
- Keywords
- Periodontal Disease; Tissue Regeneration; Cell Biology; Wound Healing
Projects listed above are funded by Australian Competitive Grants. Projects funded from other sources are not listed due to confidentiality agreements.
Supervision
Completed supervisions (Doctorate)
- Controlling whole blood activation and Resultant clot properties on various material surfaces: a possible therapeutic approach for enhancing bone healing (2013)
- Interactions between Undifferentiated and Osteogenically Differentiated Mesenchymal Stromal Cells during Osteogenesis (2013)
- The Ancient Gene C12ORF29: An Exploration of its role in the Chordate Body Plan (2013)
- Influence of Culture Conditions on the Molecular Signature of Mesenchymal Stem Cells (2011)
- Cross-talk of subchondral bone osteoblasts and articular cartilage chondrocytes: a new insight in understanding osteoarthritis pathogenesis (2010)
- Physiological Investigation of Periosteum Structure and its Application in Periosteum Tissue Engineering (2010)
- Characterisation of Mesenchymal Cells from Osteophytes in Osteoarthritis (2009)
- Characterization of Bone Marrow Stromal Clonal Populations derived from Osteoarthritis Patients (2008)