New antimicrobial compounds with biofouling properties

Overview

Bacteria can readily adhere to the surface of synthetic materials and form a biofilm which is much more difficult to combat than circulating bacteria due to their extreme resistance to antibiotics. Thus, biofilms are of particular concern in the healthcare system, where they increase infection rates by contaminating medical devices, delay chronic wound healing and contribute to tooth decay. In systems used to transport water and oil, biofilms are associated with pipe blockages and corrosion which can result decreased efficiencies and elevated maintenance costs.

This project aims to develop new molecules which will disturb the attachment and proliferation of bacteria on surfaces.

Research activities

The student will be involved with the preparation of various molecules towards the targeted anti-biofilm structures. This project will provide students with synthetic skills in organic chemistry and instrumental experience (NMR, IR, HPLC, MS) associated with compound characterisation.

Outcomes

Appreciable quantities of several new compounds for this project will be synthesised and adequately characterised.

Skills and experience

Skills in planning and carrying out synthetic organic reactions and characterising organic molecules

Scholarships

You may be eligible to apply for a research scholarship.

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Keywords

• organic chemistry
• biofilm
• antibiotics

Contact

Contact the supervisor for more information.