QUT offers a diverse range of student topics for Honours, Masters and PhD study. Search to find a topic that interests you or propose your own research topic to a prospective QUT supervisor. You may also ask a prospective supervisor to help you identify or refine a research topic.
Found 181 matching student topics
Displaying 73–84 of 181 results
Comparison of output from collocated solar systems of different technology
Solar panel efficiency is calculated using standardised testing conditions, allowing like-for-like comparison of systems under the same conditions. However, data collected over a three year period from two collocated solar systems of different technologies are showing unexpected results. The most efficient system's yearly output is comparatively lower. Initial data analysis explains some differences from the operational conditions, but further investigation is required.
- Study level
- Honours
- Faculty
- Faculty of Engineering
- School
- School of Mechanical, Medical and Process Engineering
- Research centre(s)
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Centre for Clean Energy Technologies and Practices
Understanding the genetics of melanoma susceptibility: many roads lead to DNA repair
Repair of the damage caused by mutagens such as UV and reactive oxygen species is vital to prevent cancer and premature aging and accordingly cells have developed a suite of intricate and specific DNA repair pathways. Loss or abnormal function of components of these pathways lead to cancer pre-disposition syndromes for example breast cancer in individuals carrying mutations in the BRCA1 or BRCA2 genes. Understanding the complexities of these DNA repair pathways is vital to efforts aimed at preventing or …
- Study level
- Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Understanding the role of the hSSB1 protein in the response to UV induced DNA damage
Melanoma is the 4th most common cancer in Australia. The link between skin cancer and UV exposure is now well established. If a DNA damage induced by UV exposure is left unrepaired, the mutation generated in the genome can lead to cell death or cancer. It is thus highly important to understand of how a cell can repair DNA damage. The main pathway to repair UV DNA damaged is the nucleotide excision repair pathway (NER) (Kamileri I. et al, Trends …
- Study level
- Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Investigating DNA repair mechanisms in aging adult stem cells
When we age the DNA repair systems of our cells become down regulated. This results in reduced DNA repair capacity, enhanced rates of mutation load and may lead to the development of chronic aging-associated diseases including osteoporosis, Alzheimer's and cancer(1). So it is no surprise that genome instability and stem cell exhaustion, which also strongly correlates with the accumulation of DNA damage, are considered hallmarks of aging(2).However, we still lack a clear understanding on how the decrease in DNA repair …
- Study level
- PhD, Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Characterise a novel DNA repair protein as a target for cancer therapies
Data generated in the lab has identified a novel DNA repair protein previously described as a key protein in HSP70/90 complexes. Many pathways of tumourigenesis are mediated by Heat Shock Proteins and HSP70/90 are found significantly upregulated in ovarian cancers. The targeting of HSP70/90 are an emerging therapeutic avenue for the treatment of ovarian cancer. Supporting this, an inhibitor of HSP90 has been shown to sensitise breast cancer cells to PARP inhibitors and paclitaxel.Our preliminary data indicates that this new …
- Study level
- Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Characterising the role of PARPs in DNA repair and cancer therapy
The genome of our cells is damaged multiple times each day, by various factors including sunlight and reactive oxygen species. In order for the DNA damage response to be efficient, our cells utilise highly coordinated repair pathways that function accurately and rapidly throughout the damaged cell. Cells that do not repair DNA damage correctly will accumulate damage and display increased genomic instability, which is a key hallmark of cancer cells, promoting their survival and rapid growth. DNA repair pathways are …
- Study level
- Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Curtailing corporate tax aggression through uncertain tax benefits
Over the last five years Australia has adopted numerous measures to address aggressive corporate tax practices. A recent addition to these measures (on the 1st of January 2019) is AASB Interpretation 23 - Uncertainty over Income Tax Treatments, which was developed to clarify the treatment of uncertain tax positions. This interpretation requires entities who produce general purpose financial reports (GPFRs) to disclose uncertain tax benefits (UTB) in the notes to their financial statements. Extant literature suggests that UTB disclosures are …
- Study level
- Honours
- Faculty
- Faculty of Business and Law
- School
- School of Accountancy
Multimodal AI to simulate medical student competency
The assessment of medical graduate competency is a cornerstone of medical education and a critical safeguard for patient safety. Newly qualified physicians must demonstrate a broad range of skills and knowledge, including diagnostic reasoning, clinical decision-making, communication, procedural skills, and professionalism before independently practicing medicine. Traditional assessment methods often include standardized multiple-choice examinations, objective structured clinical examinations (OSCEs), direct observation of procedural skills (DOPS), and portfolio reviews. While these methods offer valuable insights, they have inherent limitations. Standardized tests may …
- Study level
- PhD, Master of Philosophy
- Faculty
- Faculty of Health
- School
- School of Public Health and Social Work
- Research centre(s)
- Centre for Data Science
Robotic maintenance of equipment
Think about the problem of maintaining equipment at remote work sites. How can robotic technology help human maintenance staff to work more safely and productively?
- Study level
- PhD
- Faculty
- Faculty of Engineering
- School
- School of Electrical Engineering and Robotics
Efficient Parameter Estimation for Stochastic Simulations
Stochastic simulation-based models are routinely used in many areas of science to describe inherent randomness in many real-world systems. Applications include the study of particle physics, imaging if black holes, biochemical processes, the migration of animals, and the spread of infectious diseases. To apply these models to interpret data requires statistical methods to estimate model parameters.Unfortunately, standard statistical techniques are not capable of analysing data using these models. This is largely due to the model likelihood, the probability of the …
- Study level
- PhD, Master of Philosophy, Honours
- Faculty
- Faculty of Science
- School
- School of Mathematical Sciences
- Research centre(s)
- Centre for Data Science
Development of a Microfluidic Gut-Brain Axis Chip
The gut microbiome refers to the collection of micro-organisms that are living symbiotically in the human or animal gastrointestinal tract (defined as the “microbiota”), their genetic material as well as the surrounding environmental habitat. It is now appreciated that the microbiome plays an important role in human health and diseases. Many neurodegenerative diseases, such as Parkinson's Disease have been linked to dysregulation of the gut microbiota. However, it is difficult to study gut-brain axis using animal models due to inter-species …
- Study level
- PhD, Master of Philosophy
- Faculty
- Faculty of Engineering
- School
- School of Mechanical, Medical and Process Engineering
- Research centre(s)
- Centre for Biomedical Technologies
Centre for Microbiome Research
Making the most of many models
In the age of Big Data, machine learning methods, and modern statistics the adage "all models are wrong but some are useful" has never been so true. This project will investigate data science approaches where more than one model makes sense for the data. Is it better to choose a single model or is there something to be gained from multiple models?This project will look at variable selection methods, penalised regression, Bayesian model averaging and conformal prediction. The research has …
- Study level
- Honours
- Faculty
- Faculty of Science
- School
- School of Mathematical Sciences
- Research centre(s)
- Centre for Data Science
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