QUT offers a diverse range of student topics for Honours, Masters and PhD study. Search to find a topic that interests you or propose your own research topic to a prospective QUT supervisor. You may also ask a prospective supervisor to help you identify or refine a research topic.
Found 37 matching student topics
Displaying 13–24 of 37 results
Spatial profiling of the tumour microenvironment
Lung cancers are the leading cause of cancer related deaths in Australia, with a 5-year survival of 15%. With the emerging success of immune checkpoint blockage leading to durable responses and prolonged survival in 15-40% of cases, there is now a need for predictive biomarkers to guide selection for immunotherapies.The immune contexture of the tumour microenvironment (TME) is an important factor in dictating how well a tumour may respond to immune checkpoint therapies (1). Spatial and immunological composition with cellular …
- Study level
- PhD, Master of Philosophy
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Therapeutic opportunities targeting epigenetic-metabolism crosswalks in cancer
Epigenetic and metabolic pathways in cancer cells are highly interconnected. Epigenetic landscape in cancer cells is modified by oncogene-driven metabolic changes. Metabolites modulate the activities of epigenetic modifying enzymes to regulate the expression of specific genes. Conversely, epigenetic deregulation that occurs in cancer affect the expression of metabolic genes, thereby altering the metabolome. These changes all coordinately enhance cancer cell proliferation, metastasis and therapy resistance.The overall aim of the project is to understand the link between the activity of epigenetic …
- Study level
- Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Epigenetic regulation of non-coding RNAs in hypoxic tumours
In solid tumours, hypoxia occurs as a result of limitation on oxygen diffusion in avascular primary tumours or their metastases. Persistent hypoxia, significantly reduces the efficacy of radiation and chemotherapy and lead to poor outcomes. This is mainly due to increase in pro-survival genes that suppress apoptosis, enhance tumour angiogenesis, the epithelial-to-mesenchymal transition, invasiveness and metastasis. Much of tumour hypoxia research has been centred on examining the transcriptional targets of hypoxia inducible factors (HIFs).HypothesisEpigenetic changes mediate the effect of hypoxia …
- Study level
- Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Determining the theapeutic efficiency of epigenetic drugs in ovarian cancer
Because cancer and many diseases arise from a combination of genetic propensity and the response of cells to external factors mediated through changes to the expression of key genes, it is important to understand epigenetic regulation. The epigenome is crucial to the changes of gene expression and there is now strong evidence that epigenetic alterations are key drivers of cancer progression. However, very few drugs targeting epigenetic modifiers have been successful, in part due to the lack of effective means …
- Study level
- Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Assessing reef restoration using MARRS Reef Stars on the Great Barrier Reef
The Bait Reef rehabilitation project commenced in early 2021 (site surveys, risk assessments and approval processes) and installation on-site occurred in October 2021. Since installation there has been monitoring of the Reef Stars in June 2022, February 2023, and January 2024.Thermal bleaching impacts in early 2022 and rapid colonisation of the area by soft corals meant that by February 2022 more than 50% of the original coral fragments had died. Subsequently, in August 2023 all dead fragments (still attached to …
- Study level
- PhD, Master of Philosophy, Honours
- Faculty
- Faculty of Science
- School
- School of Earth and Atmospheric Sciences
- Research centre(s)
- Centre for Data Science
Information retrieval and coding methods for large scale bioinformatics
Advances in sequencing technologies over the past two decades have led to an explosion in the availability of genomic sequence data and an increasingly urgent need for scalable clustering and search facilities. One approach is to encode sequences as binary vectors in a high-dimensional space, simplifying the comparison and allowing it to be computed very rapidly using bit-level operations.Coupled with these ideas is the need to provide clustering methods and efficient indexing and lookup in response to search queries. One …
- Study level
- PhD, Master of Philosophy, Honours
- Faculty
- Faculty of Science
- School
- School of Computer Science
- Research centre(s)
- Centre for Data Science
Unified def-site and use-site security policies for component-based software systems
Securing the information manipulated by computer systems, such as privacy and integrity in social software, is a challenge. Traditional methods to impose limits on the information disclosure, such as access control lists, firewalls, and cryptography, provide no guarantees about information propagation. For instance, cryptography provides no guarantees about the confidentiality of the data are given once it is decrypted.Information flow control (IFC) is the problem of ensuring secure information flow according to specified policies within computer systems. Modern applications are …
- Study level
- PhD, Master of Philosophy
- Faculty
- Faculty of Science
- School
- School of Computer Science
Security analysis of open-source software
Several open-source projects drive modern-day IT applications. However, some open-source projects get compromised by malicious attackers, who include malware to the code to compromise the security of the application users.This project will investigate approaches for securing the open-source software.
- Study level
- Honours
- Faculty
- Faculty of Science
- School
- School of Computer Science
Big data analysis to aid ecological research
We're looking for multiple students to help us answer the question: 'How can we utilise information technology to aid ecological research?'Sensor networks bring ecologists and pattern recognition researchers together to make some applications possible. These applications include assessing risks from potential bird collisions, unobtrusive observations (where the presence of humans changes some animal behaviours) and studying spatial and temporal variation in biological processes.With a significant amount of data being collected from these applications, processing and mining this data is challenging. …
- Study level
- PhD, Master of Philosophy, Honours
- Faculty
- Faculty of Science
- School
- School of Computer Science
Enabling effective novice-expert interactions: co-designing immersive systems for complex remote data analysis
This student research topic focuses on exploring and developing immersive systems that facilitate interactions between novice and expert users in the context of complex remote data analysis. The goal is to design and prototype innovative solutions that enhance the collaboration, learning, and training aspects of data analysis tasks.The research will involve investigating various immersive technologies and their potential application in bridging the gap between novice and expert users, enabling effective knowledge transfer and skill acquisition.
- Study level
- PhD, Master of Philosophy, Honours
- Faculty
- Faculty of Science
- School
- School of Computer Science
Time-series analysis of 2D diffraction patterns for Synchrotron rock physics
The interaction between deformation, fluid flow, chemical reactions, and heat flow in rocks constitutes a research frontier in the Earth Sciences. In addition to fundamental academic interest in this subject, there are many applied industrial problems, which require a sound understanding of this coupling. Examples include: the long-term sequestration of carbon dioxide in rocks, the energy-efficient processing of future-mineral resources, the design of unconventional geothermal-energy operations, and the prediction of earthquakes and volcanic eruptions.The advisory team pioneered new methods for …
- Study level
- PhD, Master of Philosophy
- Faculty
- Faculty of Science
- School
- School of Earth and Atmospheric Sciences
- Research centre(s)
- Centre for Data Science
Metagenomic analysis of bacterial contamination screening pooled platelets
Bacterial sepsis is second only to ABO incompatibility as a cause of death from transfusion. Bacterial contamination of platelets is recognised as the most significant residual infectious risk of transfusion in developed countries. Bacterial Contamination Screening (BCS) has been required for testing of pooled and apheresis platelets manufactured by the Blood Service since April 2008. International microbiological culture studies suggest that the incidence of bacterial contamination ranges from 1:3000 to 1:1000 units of apheresis platelets and 1 in 600 to …
- Study level
- Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
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