QUT offers a diverse range of student topics for Honours, Masters and PhD study. Search to find a topic that interests you or propose your own research topic to a prospective QUT supervisor. You may also ask a prospective supervisor to help you identify or refine a research topic.
Found 6 matching student topics
Displaying 1–6 of 6 results
Scalable software solutions for improving the CRISPR gene editing system
The CRISPR-Cas9 technology allows the modification of virtually any gene in any organism of interest. It has generated a lot of interest, both in the research community and the general population.One of the crucial components of CRISPR experiments is the design of the 'guide RNAs' that will control where modifications occur. We have developed a software pipeline, named Crackling, to identify safe and effective guide RNAs across entire genomes.We are seeking to expand and improve various aspects of our current …
- Study level
- Honours
- Faculty
- Faculty of Science
- School
- School of Computer Science
- Research centre(s)
- Centre for Data Science
Visualisation of CRISPR targets
CRISPR-Cas9 technology allows us to modify virtually any gene in any organism of interest. It has generated a lot of interest, both in the research community and the general population.One of the crucial components of CRISPR experiments is the design of the 'guide RNAs' that will control where modifications occur.We have developed a software pipeline, named Crackling, to identify safe and effective guide RNAs across entire genomes. We're now seeking to develop a visualisation to communicate the results produced by …
- Study level
- Honours
- Faculty
- Faculty of Science
- School
- School of Computer Science
- Research centre(s)
- Centre for Data Science
Investigating genetic variants involved in Wilson disease and copper metabolism using genome editing
Wilson disease (WD) is a genetic disorder of copper metabolism. It can present with hepatic and neurological symptoms, due to copper accumulation in the liver and brain (1). WD is caused by compound heterozygosity or homozygosity for mutations in the copper transporting P-type ATPase gene ATP7B. Over 700 ATP7B genetic variants have been associated with WD. Estimates for WD population prevalence vary with 1 in 30,000 generally quoted. Early diagnosis and treatment are important for successful management of the disease. …
- Study level
- Master of Philosophy, Honours
- School
- School of Biomedical Sciences
- Research centre(s)
- Centre for Genomics and Personalised Health
Novel therapeutic strategies to treat advanced colorectal cancer
Colorectal cancer is a very common disease, with over 15,000 new cases diagnosed in Australia annually. Metastatic colorectal cancer describes advanced disease that has spread beyond the primary site. This is very aggressive and incurable in the vast majority of these patients. To improve outcomes for colorectal cancer, we are using cutting edge genomic and cell biology techniques to understand disease heterogeneity and optimise drug response. We are developing novel therapeutic interventions based on unique molecular signatures and are testing …
- Study level
- Master of Philosophy, Honours
- School
- School of Biomedical Sciences
High-performance scoring of CRISPR targets
The CRISPR-Cas9 technology allows the modification of virtually any gene in any organism of interest. It's generated a lot of interest, both in the research community and the general population.One of the crucial components of CRISPR experiments is the design of the "guide RNAs" that will control where modifications occur. It's vital that the modification is made at the desired location and not elsewhere.We developed a method utilising high-performance computing to efficiently assess the "off-target risk" of each guide RNA …
- Study level
- Honours
- Faculty
- Faculty of Science
- School
- School of Computer Science
- Research centre(s)
- Centre for Data Science
Capacity, wills and enduring powers of attorney
Dr Kelly Purser is interested in talking to students who wish to undertake research on the topics of capacity, wills, enduring powers of attorney, advance health directives, estate planning, equity and trusts, succession, or therapeutic jurisprudence.
- Study level
- PhD, Master of Philosophy
- School
- null
- Research centre(s)
- null
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