QUT offers a diverse range of student topics for Honours, Masters and PhD study. Search to find a topic that interests you or propose your own research topic to a prospective QUT supervisor. You may also ask a prospective supervisor to help you identify or refine a research topic.
Found 19 matching student topics
Displaying 13–19 of 19 results
Development of a machine learning algorithm for high throughput cell response data in drug therapy
High-throughput screening assays are essential for accelerating drug discovery, but current assays often rely on endpoint measurements that do not capture the dynamic response of cells to drug treatment. Machine learning algorithms (MLAs) have the potential to enable real-time, high-throughput monitoring of cell response to drug treatment by analyzing complex datasets generated by multiplexed live-cell assays. This research project aims to develop an MLA for enabling high throughput cell response data in drug treatment. The project will involve three main …
- Study level
- Honours
- School
- School of Computer Science
- Research centre(s)
- Centre for Biomedical Technologies
Centre for Biomedical Technologies
Determining the theapeutic efficiency of epigenetic drugs in ovarian cancer
Because cancer and many diseases arise from a combination of genetic propensity and the response of cells to external factors mediated through changes to the expression of key genes, it is important to understand epigenetic regulation. The epigenome is crucial to the changes of gene expression and there is now strong evidence that epigenetic alterations are key drivers of cancer progression. However, very few drugs targeting epigenetic modifiers have been successful, in part due to the lack of effective means …
- Study level
- Master of Philosophy, Honours
- School
- School of Biomedical Sciences
A preclinical evaluation pipeline for new antivirulence drugs targeting multidrug resistant bacterial pathogens
A post-antibiotic era—in which common infections and minor injuries can kill—far from being an apocalyptic fantasy, is instead a very real possibility for the 21st century.’ - WHO, 2014 (1). Antimicrobial resistance (AMR) is a global public health priority. If no action is taken, AMR is predicted to kill more people than cancer and diabetes combined by 2050, with 10 million deaths estimated each year and a global cost of up to 100 trillion USD. New therapies to tackle multidrug …
- Study level
- Master of Philosophy, Honours
- School
- School of Biomedical Sciences
Antibiotic-loaded polymer nanoparticulate inhaled formulations against lung infections associated with COPD and CF
Lower respiratory tract infections (LRTIs) are one of the fatal diseases of the lungs that have severe impacts on public health especially the Indigenous people. The currently available antibiotics administered orally for the treatment of LRTIs need high doses with frequent administration and cause dose-related adverse effects.To overcome this problem, we will investigate the development of antibiotic-loaded polymer nanoparticles (NPs) for potential pulmonary delivery from dry powder inhaler (DPI) formulations. This study will address the release profile of the antibiotic …
- Study level
- PhD
- School
- School of Clinical Sciences
- Research centre(s)
- Centre for Materials Science
Centre for Immunology and Infection Control
Targeting a novel adaptive neovascular response of the tumour microenvironment to treat advanced prostate cancer
Prostate cancer (PCa) is a significant healthcare burden in Australia. Androgen signalling inhibition using androgen receptor (AR) antagonists is the principal systemic therapy for advanced PCa. Androgen receptors (AR) are an attractive therapeutic target due to their elevated expression in tumour epithelial cells and the retention of androgen signalling throughout the disease continuum.However, patients eventually develop resistance to treatment, and PCa cells metastasise to distant bone and visceral organs, representing an incurable stage of the disease. Understanding mechanisms that contribute …
- Study level
- PhD, Master of Philosophy, Honours
- School
- School of Biomedical Sciences
BIOM01 - Novel therapeutic strategies for targeting dementia
Dementia exhibits the presence of Lewy bodies in the cerebral cortex, which are composed of α-synuclein (αSYN) or Amyloid-β (Aβ) plaques, as well as hyperphosphorylated tau (P-tau) tangles in various forms of dementia. The exact pathological mechanisms underlying this disease are not well understood; however, there is evidence suggesting the involvement of inflammatory activity. Microglia, macrophage cells residing in the brain responsible for clearing external pathogens and dead cells, are of particular interest.Our study aims to investigate whether Lewy bodies …
- Study level
- Master of Philosophy, Honours
- Faculty
- Faculty of Science
- School
- School of Biomedical Sciences
- Research centre(s)
-
Centre for Microbiome Research
Improving platinum-based chemotherapy by targeting drug metabolism in lung cancer
Lung cancer is the deadliest cancer accounting for 18.4% of all cancer-related deaths. Platinum-based chemotherapy remains a key treatment option for most people living with this disease, either as adjuvant therapy or in combination with immunotherapy. However, resistance to therapy is a significant issue in the treatment of lung cancer. Novel therapeutic strategies combined with predictive biomarkers chemotherapy response are needed to transform the clinical management of NSCLC.Our published work has identified novel biomarkers and druggable proteins from deregulated protein …
- Study level
- Master of Philosophy, Honours
- School
- School of Biomedical Sciences
- Research centre(s)
- Centre for Genomics and Personalised Health
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