QUT offers a diverse range of student topics for Honours, Masters and PhD study. Search to find a topic that interests you or propose your own research topic to a prospective QUT supervisor. You may also ask a prospective supervisor to help you identify or refine a research topic.
Found 46 matching student topics
Displaying 25–36 of 46 results
Targeting a novel adaptive neovascular response of the tumour microenvironment to treat advanced prostate cancer
Prostate cancer (PCa) is a significant healthcare burden in Australia. Androgen signalling inhibition using androgen receptor (AR) antagonists is the principal systemic therapy for advanced PCa. Androgen receptors (AR) are an attractive therapeutic target due to their elevated expression in tumour epithelial cells and the retention of androgen signalling throughout the disease continuum.However, patients eventually develop resistance to treatment, and PCa cells metastasise to distant bone and visceral organs, representing an incurable stage of the disease. Understanding mechanisms that contribute …
- Study level
- PhD, Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Engineering the prostate tumour microenvironment in organ-on-a-chip systems
Prostate cancer remains one of the leading causes of global death. The tumour microenvironment (TME) including blood vessels, immune cells, fibroblasts, and the extracellular matrix (ECM) possesses disease-specific biophysical and biological factors that are difficult to recapitulate using conventional in vitro cell culture models.The absence of these factors, however, causes cells to display abnormal morphologies, polarisation, proliferation, and drug responses, thereby limiting the ability to translate research findings from traditional cell culture into clinical practice.Recent advances in organ-on-a-chip technology enable …
- Study level
- Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Spatial profiling of the tumour microenvironment
Lung cancers are the leading cause of cancer related deaths in Australia, with a 5-year survival of 15%. With the emerging success of immune checkpoint blockage leading to durable responses and prolonged survival in 15-40% of cases, there is now a need for predictive biomarkers to guide selection for immunotherapies.The immune contexture of the tumour microenvironment (TME) is an important factor in dictating how well a tumour may respond to immune checkpoint therapies (1). Spatial and immunological composition with cellular …
- Study level
- PhD, Master of Philosophy
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Wearable neuro-imaging and spatial experience
Our built environment changes our brain function. There is considerable interest from many research fields upon the positive and negative health and wellbeing effects of our environments. This research area explores how architectural environments and spaces impact experience and mood using wearable brain-imaging technology.
- Study level
- PhD, Master of Philosophy
- Faculty
- Faculty of Engineering
- School
- School of Architecture and Built Environment
Engineering bioartificial extracellular tumour microenvironments for Osteosarcoma personalised precision oncology
Osteosarcoma (OS) is the most common malignant bone tumour affecting children and adolescents. Importantly, clinical outcomes have not improved for decades, and bone tumours remain to be a leading cause of cancer-related death in adolescents.By identifying ideal treatment approaches for each individual patient, precision oncology has the potential to significantly improve these outcomes. Yet, its widespread application is hindered by a lack of biomaterials that support the reproducible and robust generation of patient-derived osteosarcoma organoids in vitro.Therefore, this project will …
- Study level
- PhD, Master of Philosophy
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
- Research centre(s)
- Centre for Biomedical Technologies
Multi-UAV navigation in GPS denied environments
The aim of this research is to develop a framework for multiple Unmanned Aerial Vehicles (UAV), that balances information sharing, exploration, localization, mapping, and other planning objectives thus allowing a team of UAVs to navigate in complex environments in time critical situations. This project expects to generate new knowledge in UAV navigation using an innovative approach by combining Simultaneous Localization and Mapping (SLAM) algorithms with Partially Observable Markov Decision Processes (POMDP) and Deep Reinforcement learning. This should provide significant benefits, …
- Study level
- PhD
- Faculty
- Faculty of Engineering
- School
- School of Electrical Engineering and Robotics
UAV navigation in GPS denied environments
This PhD project aims to develop a framework for unmanned aerial vehicles (UAV), which optimally balances localisation, mapping and other objectives in order to solve sequential decision tasks under map and pose uncertainty. This project expects to generate new knowledge in UAV navigation using an innovative approach by combining simultaneous localisation and mapping algorithms with partially observable markov decision processes. The project’s expected outcomes will enable UAVs to solve multiple objectives under map and pose uncertainty in GPS-denied environments. This …
- Study level
- PhD
- Faculty
- Faculty of Engineering
- School
- School of Electrical Engineering and Robotics
Optimal conservation management in uncertain Antarctic environments
Species and ecosystems in Antarctica are threatened. Optimal biodiversity conservation is an interdisciplinary field combining mathematical modelling and optimisation with ecology and conservation. We can use mathematics to understand the system, model how management actions might impact it, and then optimise which actions should be used. For example, we can explore where protected areas should be placed, how species should be managed, or how tourist impacts should be reduced. However, the complexities of conservation in Antarctica necessitate the application of …
- Study level
- PhD, Master of Philosophy, Honours
- Faculty
- Faculty of Science
- School
- School of Mathematical Sciences
- Research centre(s)
- Centre for Data Science
Centre for the Environment
Adaptive evolution of anaerobic methanotrophic (ANME) archaea mediating methane oxidation in freshwater environments (PhD)
The as-yet-uncultured archaeal lineage Methanoperedenaceae are anaerobic methanotrophs with a key role in mitigating the atmospheric release of methane in freshwater environments. The metabolic diversity of these microorganisms directly links methane with several key biochemical cycles and suggests a remarkable ability of these microorganisms to adapt to diverse environmental conditions.The overall aim of this PhD project will be to uncover the metabolic diversity of the Methanoperedenaceae and to understand the evolutionary mechanisms responsible for these adaptations.Methods and ResourcesThe project will …
- Study level
- PhD
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
- Research centre(s)
-
Centre for Microbiome Research
Re-localisation in natural environments
Re-localisation in robotics involves the process of determining a robot's current pose, consisting of its position and orientation. This can either be within a previously mapped and known environment (i.e. prior map) or relative to another robot in a multi-agent setup. Re-localisation is essential for enabling robots to perform tasks such as autonomous monitoring and exploration seamlessly, even when they encounter temporary challenges in precisely tracking their location in GPS-degraded environments. For instance, consider the 'wake-up' problem, where a robot …
- Study level
- PhD
- Faculty
- Faculty of Engineering
- School
- School of Electrical Engineering and Robotics
Aerosol presursors in Australian marine environments
Aerosols, tiny solid or liquid particles, play an important role in global climate regulation, firstly, by scattering and absorbing incoming solar radiation and, secondly, by their ability to take up water vapor from the atmosphere and serve as nuclei for cloud droplet formation (Cloud Condensation Nuclei (CCN)).With oceans covering 71% of the Earth’s surface, marine aerosols present a significant proportion of the global aerosol budget. Production of particles in the marine environment occurs via 2 pathways: 1) wave breaking and …
- Study level
- PhD, Master of Philosophy
- Faculty
- Faculty of Science
- School
- School of Earth and Atmospheric Sciences
- Research centre(s)
-
Centre for the Environment
The softer side of next-gen entrepreneurship: the emotional experience and success
Next-generation (next-gen) entrepreneurs are described as people who operate solely in online environments (i.e. via the internet). The internet and mobile technologies have profoundly impacted the ways in which business is conducted, yet little is known about this new type of business environment. There has been considerable research into entrepreneurs who operate largely in physical 'bricks and mortar' settings, however the literature is limited in providing insight into entrepreneurs who operate solely in online environments.We know that emotions influence the …
- Study level
- PhD, Master of Philosophy
- School
- null
- Research centre(s)
- null
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