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Found 6 matching student topics

Displaying 1–6 of 6 results

Representation learning for anti-microbial resistance

This project is about using neural network models help us understand Anti-Microbial Resistance (AMR), a phenomenon in which bacteria adapt to reduce the effectiveness of antibiotics, usually through a process known as Lateral or Horizontal Gene Transfer - where genes are included in the organism from other sources.Our focus will be on learning compact vector representations of biological sequences known to be associated with AMR genes. By encoding DNA sequences in this way we can more rapidly identify AMR genes …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Science
School
School of Computer Science
Research centre(s)
Centre for Data Science

Understanding capsular polysaccharide diversity is key to next generation therapies for multi-drug resistant Acinetobacter baumannii infections

Bacteriophage therapy is an attractive innovative treatment for infections caused by extensively drug resistant Acinetobacter baumannii, for which there are few effective antibiotic treatments remaining.Capsular polysaccharide (CPS) is a primary receptor for lytic bacteriophage, thus knowledge of the chemical structures of CPS produced by the species underpins the identification of suitable phage for therapeutic cocktails.As many phage depolymerases cleave a specific CPS linkage formed by either a glycosyltransferase or polymerase enzyme, characterisation of these proteins are essential.However, these remain largely …

Study level
PhD
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Centre for Immunology and Infection Control

A preclinical evaluation pipeline for new antivirulence drugs targeting multidrug resistant bacterial pathogens

A post-antibiotic era—in which common infections and minor injuries can kill—far from being an apocalyptic fantasy, is instead a very real possibility for the 21st century.’ - WHO, 2014 (1). Antimicrobial resistance (AMR) is a global public health priority. If no action is taken, AMR is predicted to kill more people than cancer and diabetes combined by 2050, with 10 million deaths estimated each year and a global cost of up to 100 trillion USD. New therapies to tackle multidrug …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences

New antimicrobial compounds with biofouling properties

Bacteria can readily adhere to the surface of synthetic materials and form a biofilm which is much more difficult to combat than circulating bacteria due to their extreme resistance to antibiotics. Thus, biofilms are of particular concern in the healthcare system, where they increase infection rates by contaminating medical devices, delay chronic wound healing and contribute to tooth decay. In systems used to transport water and oil, biofilms are associated with pipe blockages and corrosion which can result decreased efficiencies …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Science
School
School of Chemistry and Physics
Research centre(s)
Centre for Materials Science

Multi-microbial 3D printing for screening microbiome functions

The ability to 3D print bacteria has relevance to a wide range of applications, ranging from developing novel anti-microbial modalities to probiotics for promoting human health. Traditional culture techniques used in microbiology such as agar plates and suspension cultures have limited spatio-temporal control over the bacteria microenvironment as well as their interaction partners, in particular, mammalian host cells. This project aims to bridge this technological gap by combining 3D printing and microfluidics technologies to spatially control the localisation of multiple …

Study level
PhD, Master of Philosophy
Faculty
Faculty of Health
School
School of Biomedical Sciences

‘race for the surface’: designing the next generation antimicrobial biomaterials

When a biomaterial is implanted into the body and bacteria get into the implantation site, both the bacteria and tissue cells actively seek to establish their colonization on the biomaterial surface. This process, called ‘the race for the surface’ by Anthony Gristina in 1987, is still a subject of intense investigation. It is generally accepted that a biomaterial’s success in integrating with the body depends on if tissue cells win or the bacteria win the race. However, evidence from the …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Business and Law
School
School of Accountancy

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