QUT offers a diverse range of student topics for Honours, Masters and PhD study. Search to find a topic that interests you or propose your own research topic to a prospective QUT supervisor. You may also ask a prospective supervisor to help you identify or refine a research topic.
Found 5 matching student topics
Displaying 1–5 of 5 results
Identifying novel pheno-endotypes in children with chronic cough
Chronic wet cough is among the commonest symptoms of chronic lung disease. In Australia, the most common cause of childhood chronic wet cough is protracted bacterial bronchitis (PBB), a clinical entity we first described. It has now been shown to be a precursor to bronchiectasis, which causes substantial morbidity and mortality, especially from acute respiratory exacerbations. Lung inflammation in children with persistent chronic wet cough is an important driver of ongoing and progressive tissue damage, leading to bronchiectasis, highlighting the …
- Study level
- PhD
- Faculty
- Faculty of Health
- School
- School of Public Health and Social Work
- Research centre(s)
- Centre for Healthcare Transformation
Australian Centre for Health Services Innovation
Unleashing the full potential of terminators for the regulation of gene expression in plants
Ultimately, the proper development of a plant and its ability to adapt to its environment is the result of how plants’ genes are expressed and interact with each other. Hence, it is of extreme importance to understand the mechanisms used by plants to regulate gene expression.Modification of the expression pattern of a gene is particularly important in modern biology. By changing the expression levels of a gene, it is possible to learn about its function, increase the production of a …
- Study level
- PhD, Master of Philosophy, Honours
- Faculty
- Faculty of Science
- School
- School of Biology and Environmental Science
- Research centre(s)
- Centre for Agriculture and the Bioeconomy
Therapeutic opportunities targeting epigenetic-metabolism crosswalks in cancer
Epigenetic and metabolic pathways in cancer cells are highly interconnected. Epigenetic landscape in cancer cells is modified by oncogene-driven metabolic changes. Metabolites modulate the activities of epigenetic modifying enzymes to regulate the expression of specific genes. Conversely, epigenetic deregulation that occurs in cancer affect the expression of metabolic genes, thereby altering the metabolome. These changes all coordinately enhance cancer cell proliferation, metastasis and therapy resistance.The overall aim of the project is to understand the link between the activity of epigenetic …
- Study level
- Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Epigenetic regulation of non-coding RNAs in hypoxic tumours
In solid tumours, hypoxia occurs as a result of limitation on oxygen diffusion in avascular primary tumours or their metastases. Persistent hypoxia, significantly reduces the efficacy of radiation and chemotherapy and lead to poor outcomes. This is mainly due to increase in pro-survival genes that suppress apoptosis, enhance tumour angiogenesis, the epithelial-to-mesenchymal transition, invasiveness and metastasis. Much of tumour hypoxia research has been centred on examining the transcriptional targets of hypoxia inducible factors (HIFs).HypothesisEpigenetic changes mediate the effect of hypoxia …
- Study level
- Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Determining the theapeutic efficiency of epigenetic drugs in ovarian cancer
Because cancer and many diseases arise from a combination of genetic propensity and the response of cells to external factors mediated through changes to the expression of key genes, it is important to understand epigenetic regulation. The epigenome is crucial to the changes of gene expression and there is now strong evidence that epigenetic alterations are key drivers of cancer progression. However, very few drugs targeting epigenetic modifiers have been successful, in part due to the lack of effective means …
- Study level
- Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
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