QUT offers a diverse range of student topics for Honours, Masters and PhD study. Search to find a topic that interests you or propose your own research topic to a prospective QUT supervisor. You may also ask a prospective supervisor to help you identify or refine a research topic.
Found 476 matching student topics
Displaying 361–372 of 476 results
Understanding the genetics of melanoma susceptibility: many roads lead to DNA repair
Repair of the damage caused by mutagens such as UV and reactive oxygen species is vital to prevent cancer and premature aging and accordingly cells have developed a suite of intricate and specific DNA repair pathways. Loss or abnormal function of components of these pathways lead to cancer pre-disposition syndromes for example breast cancer in individuals carrying mutations in the BRCA1 or BRCA2 genes. Understanding the complexities of these DNA repair pathways is vital to efforts aimed at preventing or …
- Study level
- Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
An airway chip for screening viral infection mediated immune responses
Respiratory infections such as influenza, SARS-COV-2, , and MERS are increasingly prevalent. Complications and related deaths arising from these infections are often the result of a “cytokine storm”, whereby there is an over production of proinflammatory soluble factors by immune cells, which dictates symptoms severity and mortality risk [1]. Recent works showed that immunomodulatory therapy with or without antiviral agents may improve recovery outcome. However, the screening of suitable immune-modulatory and antiviral agents relies heavily on animal models which cannot …
- Study level
- PhD, Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Characterising drivers of melanoma cell heterogeneity
Tumour cell heterogeneity is linked to tumour progression through the generation of divergent cellular behaviours such as proliferation, survival, invasion and therapy resistance. Crucially, conventional and targeted therapies generally only target highly proliferative cells in tumours leading to initial tumour regression, however alternative sub-populations underpin the return of treatment refractory disease and facilitate metastatic spread. Our laboratory is focused on understanding the regulatory drivers of cellular plasticity in melanoma to better understand progression and metastatic spread of this disease and …
- Study level
- Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Creation of fibrous tissue at moving interfaces
Extracellular matrix (ECM) secreted by cells is composed of a meshwork of fibres infiltrated with proteins and/or minerals. This fibre meshwork often matures after its creation by rearranging its structure according to local mechanical clues, or by the infiltration of new molecules.In this project, the fibre meshwork will be represented by a continuous anisotropic field. You will derive evolution equations to describe fibre creation at moving cell membranes and the subsequent maturation of the meshwork.Applications of this model include the:investigation …
- Study level
- PhD, Master of Philosophy, Honours
- Faculty
- Faculty of Science
- School
- School of Mathematical Sciences
- Research centre(s)
- Centre for Biomedical Technologies
Emergence of curvature-dependent growth in mathematical models of tissue invasion
The growth of biological tissues in 3D-printed scaffold pores occurs under strong geometric controls depending on the shape and size of the pores. How this control emerges from the interaction between spatial constraints and biological processes such as cell migration and cell proliferation remains largely unknown. Existing phenomenological models of tissue growth hypothesise growth laws which directly involve curvature without considering cellular mechanisms.Recently, a reaction–diffusion mathematical model of tissue growth in porous scaffolds was proposed to investigate cell-level behaviour using …
- Study level
- PhD, Master of Philosophy, Honours
- Faculty
- Faculty of Science
- School
- School of Mathematical Sciences
- Research centre(s)
- Centre for Biomedical Technologies
Spatial localisation of immunoglobulin A in the gastrointestinal tract.
Blood cancers, which include leukaemia, lymphoma and myeloma account for 10% of all cancers and 9.4% of cancer deaths. Stem cell transplantation (SCT) is the predominant curative therapy for these diseases. However, a major complication is graft-versus-host disease (GVHD) in which the gastrointestinal (GI) tract, skin, lung and liver are preferentially damaged by the transplanted donor immune system, limiting the therapeutic potential of this treatment. Thus, there is a pressing need for new treatment approaches to improve transplant outcome for …
- Study level
- Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Understanding the immunological mechanisms that regulate increased susceptibility to respiratory syncytial viral infection after stem cell transplantation
Allogeneic stem cell transplantation (alloSCT) is considered the gold standard procedure for the treatment of blood cancers. Globally, over 9000 patients per year undergo this high-risk, life-saving therapy. However, major complications limit the therapeutic potential of this treatment which include graft-versus-host disease (GVHD) and infections due to the severe immunosuppression in these patients. Respiratory syncytial viral (RSV) infection is frequent in these patients, is often fatal and clearly a significant clinical problem. Thus, there is a pressing need for new …
- Study level
- PhD, Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Engineering Chimeric Antigen Receptor (CAR) T cell for the treatment of cancer
Chimeric Antigen Receptor (CAR) T cells are genetically modified immune cells that can recognise and kill cancer cells. They do so through the CAR, which recognises specific antigens expressed on cancer cells. CAR T cell therapy has emerged as an effective form of cancer immunotherapy in certain types of blood cancers and are now approved for use in patients. However, CAR T cell therapy can only benefit a very small proportion of cancer patients at present because it is very …
- Study level
- Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Exploring the attributes that influence the purchase of indigenous art and souvenirs
What attributes influence a consumers' intention to purchase indigenous art and souvenirs? Research has suggested ‘perception of authenticity’ motivate some consumers to seek out and purchase such products. However, authenticity may relate to the marker/artist, aesthetics of the design, or material use. These attributes are identified through the extant literature in indigenous art and souvenirs. The purpose of this research project is to determine what influences perceptions of authenticity, leading to purchase intention.
- Study level
- PhD, Master of Philosophy
- Faculty
- Faculty of Business and Law
- School
- School of Advertising, Marketing and Public Relations
The gender profile of the insolvency profession
Given the advances in representation by women in business leadership and accountancy profession generally, is it inevitable that there remain 'gendered occupational niches'?This project investigates the nature of professional work undertaken by insolvency practitioners and profiles the state of the profession to examine whether there are any isolating influences or barriers to entry for one gender or the other. It will identify the key determinants to effective performance to the role of insolvency practitioner and whether any systemic biases become …
- Study level
- Master of Philosophy
- Faculty
- Faculty of Business and Law
- School
- School of Accountancy
Understanding local government artificial intelligence policy landscape
Artificial intelligence (AI) is driving transformation across all areas of society today. An umbrella term encompassing a range of technologies both sophisticated and simple that are used to make predictions, inferences, recommendations, or decisions with data. AI is used in many products and services that people use, interact with, or are impacted by every day. It already in place of local government and assisting government officials in providing services effectively and conduct their activities more efficiently to the public. The …
- Study level
- PhD, Master of Philosophy, Honours
- Faculty
- Faculty of Engineering
- School
- School of Architecture and Built Environment
Can 'humanisation' reduce customer aggression?
As a direct response to increasing customer aggression, employee associations (unions) are implementing measures to keep frontline team members safe. One such tactic was an ‘under-name-badge’ message (“I’m someone’s daughter”, “I’m someone’s dad”). Concerningly, there is a dearth of research into the effect of such messaging.Does alerting an aggressive customer to the fact the frontline team member is ‘someone’s daughter/son’ mitigate aggression? Alternatively, does alerting an aggressive customer to the fact the frontline team member is ‘a local/attends a local …
- Study level
- PhD, Master of Philosophy
- Faculty
- Faculty of Business and Law
- School
- School of Advertising, Marketing and Public Relations
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