QUT offers a diverse range of student topics for Honours, Masters and PhD study. Search to find a topic that interests you or propose your own research topic to a prospective QUT supervisor. You may also ask a prospective supervisor to help you identify or refine a research topic.
Found 10 matching student topics
Displaying 1–10 of 10 results
Novel therapeutic strategies to treat advanced colorectal cancer
Colorectal cancer is a very common disease, with over 15,000 new cases diagnosed in Australia annually. Metastatic colorectal cancer describes advanced disease that has spread beyond the primary site. This is very aggressive and incurable in the vast majority of these patients. To improve outcomes for colorectal cancer, we are using cutting edge genomic and cell biology techniques to understand disease heterogeneity and optimise drug response. We are developing novel therapeutic interventions based on unique molecular signatures and are testing …
- Study level
- Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Characterisation of a novel protein co-amplified with the n-MYC oncogene
The MYCN oncogene is amplified in a number of tumour types, including Neuroblastoma (NB) and Neuroendocrine Prostate Cancer (NEPC), where it is associated with worse patient prognosis, as compared to non-amplified tumours. However, the high expression of MYCN (encoding the n-MYC protein) alone in non-amplified tumours is associated with better patient prognosis and less aggressive disease. This suggests that other genes co-expressed in MYCN amplified tumours may be responsible for mediating the aggressive traits of n-MYC. Our team has identified …
- Study level
- PhD, Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
- Research centre(s)
- Centre for Genomics and Personalised Health
A novel molecular targeted therapy for anaplastic prostate cancer
In advanced PCa, where the cancer has spread into the bone and other organs, the emergence of treatment resistance remains inevitable. For decades the primary form of treatment in advanced PCa has been to target the production and actions of male sex hormones, androgens, the primary developmental and survival factor of prostate tissue. While these therapies result in tumour regression and cancer control, this is temporary and treatment resistance occurs, referred to as castrate resistant prostate cancer (CRPC). In the …
- Study level
- Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Development of a microfluidic sample processing integrated robot (micro SPIN-R)
Microfluidic devices are increasingly relied upon to address the complexity of in-vitro disease models that are intended to mimic and provide insight into in-vivo processes and reactions to novel therapies and in turn, can become powerful companion diagnostic devices essential for predicting and individual patient’s reaction to a particular treatment. However, as these microfluidic devices become more and more prominent and necessary for addressing the drug screening and disease modeling needs of the industry, we have observed a lack in …
- Study level
- PhD, Master of Philosophy
- Faculty
- Faculty of Engineering
- School
- School of Mechanical, Medical and Process Engineering
- Research centre(s)
- Centre for Biomedical Technologies
Investigating immunosuppression downstream of activated FGFR2 in endometrial cancer
FGFR2 encodes two alternatively spliced isoforms that differ in their ligand binding domain and the combination of tissue specific expression of these isoforms and tissue specific expression of the FGF ligands is the foundation of normal paracrine signalling. Isoform switching from FGFR2b (inclusion of exon 8) to FGFR2c (inclusion of exon 9) occurs in tumorigenesis as it establishes an autocrine loop in epithelial cancer cells. Our lab has reported that FGFR2 activation by mutations or isoform switching is associated with …
- Study level
- PhD
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
5G and IoT smart ontology learning
This project aims to investigate privacy preservation protocols in a 5G integrated IoT environment through an analysis of the depth of smart-device use in common smart domains. 5G’s addition to IoT-based smart devices will be effectively deployed and utilised by a large majority of individual and organisation-based users. The knowledge-based ontology and tools developed in the project will help form the new privacy preservation mechanisms that are required for the 5G enabled environment.The development of an ontology for 5G enabled …
- Study level
- PhD, Honours
- Faculty
- Faculty of Science
- School
- School of Computer Science
- Research centre(s)
- Centre for Data Science
SafeAge product safety
Older persons as a cohort are at high risk of consumer product-related injury and death. The most recent Australian research into product safety issues for older persons was conducted over 25 years ago, yet the marketplace and product technology have changed dramatically and the population at risk has grown.This Australian Research Council funded Discovery Project aims to generate contemporary knowledge of the role of consumer products in injuries and deaths for older persons. It is a 3-year collaborative academic research …
- Study level
- PhD
- School
- School of Public Health and Social Work
- Research centre(s)
- Centre for Healthcare Transformation
Australian Centre for Health Services Innovation
What do ancient granitic rocks tell about the formation of Earth's crust
The Earth is a dynamic evolving planet that has continually changed throughout its history. This change is recorded in the different rock types preserved in the continental crust and is paralleled by the evolution of life. Study of Archean granitic terranes (4.0-2.5 billion years ago) provides invaluable information on the early Earth when 50% of the present day volume of continental crust was generated. You will help work out how Earth's earliest crust formed through:potential field workpetrographygeochemical analysis.
- Study level
- PhD, Master of Philosophy, Honours
- Faculty
- Faculty of Science
- School
- School of Earth and Atmospheric Sciences
Developing a precision oncology workflow for Osteosarcoma treatment
Osteosarcoma (OS) is the most common malignant bone tumour that primarily affects children and adolescents. With approximately 400 diagnosed cases/year in Australia, OS has the lowest survival rate of all solid cancers and is the leading cause of cancer-related death in Queensland adolescents. Unfortunately, 3 in 4 patients will not survive longer than five years following diagnosis with metastatic OS. Clinical “one size fits all” treatment strategies results in highly variable and unacceptably poor patient responses. Shockingly, both the OS …
- Study level
- PhD, Master of Philosophy
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
- Research centre(s)
- Centre for Biomedical Technologies
Engineering bioartificial extracellular tumour microenvironments for Osteosarcoma personalised precision oncology
Osteosarcoma (OS) is the most common malignant bone tumour affecting children and adolescents. Importantly, clinical outcomes have not improved for decades, and bone tumours remain to be a leading cause of cancer-related death in adolescents.By identifying ideal treatment approaches for each individual patient, precision oncology has the potential to significantly improve these outcomes. Yet, its widespread application is hindered by a lack of biomaterials that support the reproducible and robust generation of patient-derived osteosarcoma organoids in vitro.Therefore, this project will …
- Study level
- PhD, Master of Philosophy
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
- Research centre(s)
- Centre for Biomedical Technologies
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