QUT offers a diverse range of student topics for Honours, Masters and PhD study. Search to find a topic that interests you or propose your own research topic to a prospective QUT supervisor. You may also ask a prospective supervisor to help you identify or refine a research topic.
Found 2 matching student topics
Displaying 1–2 of 2 results
Biological and clinical impact of the association of germline variations in KLK3 (PSA) gene in prostate cancer
Prostate cancer is the most frequently occurring cancer (after skin cancers) in Australian males, and the second most common cause of cancer death. While the 5-year survival rate for localised disease approaches 100%, extra-prostatic invasion results in a poorer prognosis. Kallikreins are serine proteases, which are part of an enzymatic cascade pathway activated in prostate cancer (Lawrence et al 2010). The most well-known member is prostate specific antigen (PSA) or the KLK3 protein, encoded by the Kallikrein 3 (KLK3) gene, …
- Study level
- PhD, Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Unravelling the function of PSA variants in prostate cancer
OverviewProstate cancer (PCa) is the second-most common cancer in men. Prostate-specific antigen (PSA) encoded by the KLK3 gene is the only FDA-approved PCa biomarker for PCa. As a serine protease, PSA can also regulate multiple functions involved in PCa progression and metastasis and is summarised in our recent publications. Immunotherapies, including PSA-targeting therapies, have shown modest improvement in survival, for only a subset of metastatic PCa patients. Not much is known on the immunoregulatory role of PSA or its variants, …
- Study level
- PhD, Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
- Research centre(s)
- Centre for Genomics and Personalised Health
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