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Characterizing effects of radiation therapy in 3D bioengineered cancer models

Radiation therapy (RT) is one of the most commonly used modalities in cancer treatment, usually delivered in combination with surgical intervention, chemotherapy, and immunotherapy.However, clinical outcomes show that almost 20% of patients fail to achieve targeted outcomes because of inherent resistance to radiation. This necessitates in-depth understanding of radiation resistance mechanisms using relevant preclinical models of RT. Previous in vitro studies have predominantly used two-dimensional (2D) cell culture models that do not recapitulate the three-dimensional (3D) complexity of native tissues.

Study level
Honours
School
School of Mechanical, Medical and Process Engineering
Research centre(s)
Centre for Biomedical Technologies

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