QUT offers a diverse range of student topics for Honours, Masters and PhD study. Search to find a topic that interests you or propose your own research topic to a prospective QUT supervisor. You may also ask a prospective supervisor to help you identify or refine a research topic.
Found 3 matching student topics
Displaying 1–3 of 3 results
Investigating differences in downstream signalling mediated by two isoforms of FGFR2 in endometrial cancer
FGFR2 encodes two alternatively spliced isoforms that differ in their ligand binding domain and the combination of tissue specific expression of these isoforms and tissue specific expression of the FGF ligands is the foundation of normal paracrine signalling. Isoform switching from FGFR2b (inclusion of exon 8) to FGFR2c (inclusion of exon 9) occurs in tumorigenesis as it establishes an autocrine loop in epithelial cancer cells.We have previously published a detailed investigation into differences between wildtype FGFR2b and mutant FGFR2b following …
- Study level
- Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Genome to phenome: exploiting multi-omics and deep learning strategies to decipher importance of isoforms in health and behaviour
The molecular process that leads to multiple mRNA transcripts being produced from the same segment of DNA (aka gene) is known as alternative splicing (AS). This is a common form of regulation in higher eukaryotes, enabling the production of novel protein isoforms, which in turn are known to have a big impact on phenotype. Understanding the regulatory factors involved in AS, including epigenetic mechanisms such as DNA methylation, will offer key insights into important biological phenomena (health disease, behaviour, production). …
- Study level
- PhD
- Faculty
- Faculty of Science
- School
- School of Biology and Environmental Science
Identification and characterisation of IRX4 isoforms as novel targets in prostate cancer
Prostate cancer (PCa) is the second leading cause of cancer-related death in Australian men. There is no cure for advanced prostate cancer patients who develop resistance to currently available treatments. Alternative splicing (AS) is tightly regulated to maintain genomic stability in humans (Liyanage et al 2019). Aberrant RNA splicing of cancer-causing genes has been reported as a major cause of treatment escape in prostate cancer patients. Iroquois-class homeodomain protein 4 (IRX4) is a TALE homeobox transcription factor which has been …
- Study level
- PhD, Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
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