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Found 4 matching student topics

Displaying 1–4 of 4 results

Parameter identifiability for stochastic processes in biological systems

Stochastic models are used in biology to account for inherent randomness in many cellular processes, for example gene regulatory networks. Noise is often thought to obscure information, however, there is an increasing understanding that some randomness contains vitally important information about underlying biological processes.When applying these models to interpret and learn from data, unknown parameters in the model need to be estimated. However, not all data will contribute to a given estimation task regardless of the data quantity and quality. …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Science
School
School of Mathematical Sciences
Research centre(s)
Centre for Data Science

Scalable Bayesian Inference using Multilevel Monte Carlo

Bayesian inference is a popular statistical framework for estimating the parameters of statistical models based on data. However, Bayesian methods are well known to be computationally intensive. This fact inhibits the scalability of Bayesian analysis for real-world applications involving complex stochastic models. Such models are common in the fields of biology and ecology.Multilevel Monte Carlo (MLMC) methods are a promising class of techniques for dealing with the scalability challenge. These approaches use hierarchies of approximations to optimise the trade-off between …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Science
School
School of Mathematical Sciences
Research centre(s)
Centre for Data Science

Efficient parameter estimation for agent-based models of tumour growth

Cancer is an extremely heterogeneous disease, particularly at the cellular level. Cells within a single cancerous tumour undergo vastly different rates of proliferation based on their location and specific genetic mutations. Capturing this stochasticity in cell behaviour and its effect on tumour growth is challenging with a deterministic system, e.g. ordinary differential equations, however, is possible with an agent-based model (ABM). In an ABM, cells are modelled as individual agents that have a probability of proliferation and movement in each …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Science
School
School of Mathematical Sciences
Research centre(s)
Centre for Data Science

Topics in computational Bayesian statistics

Bayesian statistics provide a framework for a statistical inference for quantifying the uncertainty of unknowns based on information pre and post data collection.This information is captured in the posterior distribution, which is a probability distribution over the space of unknowns given the observed data.The ability to make inferences based on the posterior essentially amounts to efficiently simulating from the posterior distribution, which can generally not be done perfectly in practice.This task of sampling may be challenging for various reasons:The posterior …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Science
School
School of Mathematical Sciences
Research centre(s)
Centre for Data Science

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