QUT offers a diverse range of student topics for Honours, Masters and PhD study. Search to find a topic that interests you or propose your own research topic to a prospective QUT supervisor. You may also ask a prospective supervisor to help you identify or refine a research topic.
Found 7 matching student topics
Displaying 1–7 of 7 results
Polymer theranostics for nanomedicine
The personalised treatment of disease though nanomedicine will allow for more effective and safer treatments for patients. Polymer theranostics provide for the simultaneous detection of disease, treatment, and monitoring of therapeutic response. Our research group synthesises new polymeric materials and investigates how they can be used in applications such as:potent antivirals to fight future pandemicsthe effect of radiation on materials for improved radiotherapy for cancerresponsive imaging agents that can report on metabolic processes of diseasecharacterizing the interaction of polymeric materials …
- Study level
- PhD, Master of Philosophy, Honours
- Faculty
- Faculty of Science
- School
- School of Chemistry and Physics
- Research centre(s)
- Centre for Materials Science
Estimating the evolutionary history of plasmids and viruses
In the case of cellular life - bacteria, archaea and eukaryotes - determining the 'tree of life' is a comparatively well-studied problem.This vertical evolutionary history can be estimated using concatenated gene phylogenies, where single copy marker genes are concatenated into a single multiple sequence alignment which is then used in a phylogenetic tree reconstruction algorithm.Viral genomes and plasmid sequences, meanwhile, are more challenging to fit into a phylogenetic framework.
- Study level
- PhD, Master of Philosophy, Honours
- School
- School of Biomedical Sciences
- Research centre(s)
-
Centre for Microbiome Research
Giant viruses in the human gut microbiome
The human body is home to a vast ecosystem of microorganisms including bacteria, archaea, fungi, viruses, and bacteriophages that make up the human microbiota. These microbes and their collective genetic material, known as the microbiome, influence a wide range of physiological functions including nutrient production and absorption, the development and regulation of our immune system, protection against potential pathogens, and even our mood and mental health. While distinct microbial communities exist throughout the body, the gut microbiome has gained particular …
- Study level
- Master of Philosophy, Honours
- School
- School of Biomedical Sciences
- Research centre(s)
-
Centre for Microbiome Research
Virus Search Algorithms
Meta-heuristics are powerful search algorithms for solving intractable optimization problems. There are many population based approaches, like genetic algorithms, evolutionary algorithms, particle swarm, etc. but most of these have a static population size.Viruses arise and attack populations periodically. They typically appear when populations become abundant. Viruses infect population members, and often reduce the number of individuals. Viruses create spaces for more individuals and balance competition.The concept of viruses may be mimicked and could be a useful optimization paradigm.
- Study level
- Honours
- Faculty
- Faculty of Engineering
- School
- School of Mechanical, Medical and Process Engineering
Can virus-based defective interfering particles (DIPS) be used to treat dengue infection?
Infection by dengue virus causes incapacitating and potentially dangerous acute disease in humans. Dengue is a mosquito-borne infectious disease with about 100 million serious clinical infections annually. Considerable effort in drug development is underway, but no effective drug therapy is available. A major difficulty for drug development is the rapid evolution of RNA viruses, like dengue virus, which presents a major challenge for controlling virus transmission and infection using conventional pharmaceuticals and vaccines.This project is based on the observation that …
- Study level
- Master of Philosophy
- School
- School of Biomedical Sciences
Potential for defective interfering particles (DIPS) to interrupt mammal-mosquito transmission of dengue virus
Dengue is a major mosquito-borne disease affecting 390 million people annually across 100 countries. Disease results from infection with dengue viruses, which are single positive-stranded RNA viruses in the family Flaviviridae. Defective interfering particles (DIPs) are virus-like particles with greatly reduced genomes that are byproducts of RNA virus replication and replicate only in the presence of standard virus (Vignuzzi and Lopez 2019, doi: 10.1038/s41564-019-0465-y). DIPs occur naturally during Dengue infection (Li et al. 2011, doi: 10.1371/journal.pone.0019447) and suppress DENV replication …
- Study level
- Master of Philosophy
- School
- School of Biomedical Sciences
Characterisation of emerging multidrug resistant E. coli pathogens
The last fifteen years have witnessed an unprecedented rise in the rates of antimicrobial resistance among Gram-negative bacteria, described by the World Health organisation as a global health crisis (1). Escherichia coli sequence type 131 (E. coli ST131) is a ‘high-risk’ group of Gram-negative pathogens that have emerged rapidly and spread worldwide in the period of the last 10 years (2). E. coli ST131 strains are typically resistant to multiple classes of antibiotics and cause bloodstream and urinary tract infections …
- Study level
- Master of Philosophy, Honours
- School
- School of Biomedical Sciences
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