Faculty/School

Faculty of Engineering

School of Mechanical, Medical and Process Engineering

Topic status

We're looking for students to study this topic.

Research centre

Centre for Biomedical Technologies

Australia-China Centre for Tissue Engineering and Regenerative Medicine

Supervisors

Professor Zhiyong Li
Position
Professor
Division / Faculty
Faculty of Engineering

Overview

Excessive clotting (thrombosis) leads to the cardiovascular diseases such as heart attack and stroke, killing one Australian every 12 minutes. It has long been recognized that platelets play a central role in thrombosis and are unique in their ability to form stable adhesive interactions under conditions of rapid blood flow.

We've recently discovered a new ‘biomechanical’ prothrombotic mechanism that highlights the remarkable platelet sensitivity to the shear stress gradients of blood flow disturbance. Importantly, we've found that current anti-thrombotic drugs, such as Aspirin, Plavix® or Brilinta®, have limited effect against this biomechanical thrombosis.

To address this pressing need, we're developing simple-to-use, high-throughput and highly-informative microfluidic biochips to understand the sequences of molecular events underlying biomechanical thrombosis (mechanobiology). We're also developing computational fluid dynamics (CFD) simulation to correlate the haemodynamic parameters with thrombotic phenotypes.

We're assembling a team of bioengineers and clinicians to develop novel strategies for diagnosis and treatment of cardiovascular diseases and diabetes.

Research engagement

The research activities you're involved in will depend on your study level. They can include:

  • microfluidics design
  • 3D printing
  • fluid dynamics simulation
  • cell culture
  • in vitro experiments.

Research activities

work with a multidisciplinary team. Home - Cardiovascular Technology Laboratory (qut.edu.au)

Outcomes

The anticipated outcome could translate into point-of-care tools that:

  • facilitate physicians' decisions on diagnosis
  • follow disease progression
  • optimise treatment courses
  • potentially deploy on ambulance to improve patient care.

Skills and experience

To be considered for this research project, you should have a background in either:

  • mechanical engineering
  • chemical engineering
  • biomedical engineering background.

We also expect you to have some basic knowledge in fluid dynamics or biology.

Start date

1 November, 2024

End date

21 February, 2025

Location

GP O401H

Keywords

Contact

zhiyong.li@qut.edu.au