Faculty/School

Faculty of Health

School of Biomedical Sciences

Topic status

We're looking for students to study this topic.

Research centre

Supervisors

Adjunct Associate Professor Tracy O'Mara
Position
Adjunct Associate Professor
Division / Faculty
Faculty of Health

External supervisors

  • Dr Nathan Ingold, QIMR Berghofer

Overview

Endometrial cancer is the most commonly diagnosed invasive gynaecological cancer in developed countries. Through leadership of the Endometrial Cancer Association Consortium (ECAC), our lab runs the largest genetic study of endometrial cancer. To date, we have identified 21 genetic regions associated with endometrial cancer predisposition by genome-wide association study (GWAS), which account for ~25% of the genetic heritability of endometrial cancer risk attributable to common genetic variants. Our lab continues to explore these genetic regions to try to elucidate what drives endometrial cancer risk.

Research engagement

Computational biology, statistical genetics

Research activities

This project will use post-GWAS analyses such as LD Score Regression and Mendelian randomization to help elucidate the relationship between endometrial cancer and potential/known risk factors.

Outcomes

To use computational approaches to identify and explore risk factors of endometrial cancer. To use genetic data to construct and test risk prediction models for endometrial cancer.

Skills and experience

Basic understanding of genetics; Interest in learning how to handle big data; Interest in scripting/coding

Start date

1 November, 2024

End date

21 February, 2025

Location

QIMR Berghofer MRI, 300 Herston Rd, Herston

Keywords

Contact

A/Prof Tracy O'Mara, 07 3362 0389, Tracy.OMara@qimrberghofer.edu.au